Generic
Atropine Sulphate 1% eye prep
13 brands available in the market
At a glance
Atropine Sulphate 1% eye prep is an anticholinergic agent used for mydriasis and cycloplegia.
Description
Atropine is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues. It also has mydriatic and cycloplegic effect.
Indications
- Keratitis
- Iritis
- Cyclitis
- Refractive procedure in children
- Mydriasis and cycloplegia
Therapeutic class
Anticholinergics
Pharmacological class
Anticholinergic Agent
Pharmacology
Atropine is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues.
Mechanism of action
Atropine blocks muscarinic receptors, causing pupillary dilation and ciliary muscle paralysis.
Dosage
Adult - Inflammatory eye disorders: 1-2 drops of 1% solution up to 4 times daily.
Adult - Eye refraction: 1 drop of 1% solution twice daily for 1-2 days before procedure.
Child - Inflammatory eye disorders: 1 drop of 1% solution up to 3 times daily.
Child - Eye refraction: 1-2 drops of 0.5% solution twice daily for 1-3 days before procedure.
Administration
For ophthalmic use only. Hold the dropper close to the eye without touching it.
Missed dose
If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.
Side effects
Common: Eye irritation, hyperemia, edema, dry eyes, dermatitis, blurred vision, increased intraocular pressure.
Serious: Systemic toxicity in children.
Precautions & warnings
Toxic systemic reaction may occur in the very young and very old. Children are at higher risk of systemic toxicity.
Contraindications
Narrow angle glaucoma.
Drug interactions
Quinidine, antidepressants, some antihistamines: Additive anticholinergic effects.
Food interactions
Can be used with or without food.
Use in pregnancy
Pregnancy Category C. Atropine may be unsafe during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Trace amounts enter breast milk. AAP Committee states 'compatible with nursing'; use with caution.
Pediatric use
Children are at higher risk of systemic toxicity.
Geriatric use
Elderly patients are at higher risk of toxic systemic reactions.
Renal / hepatic impairment
No special precautions necessary.
Overdose effects
Excessive use may cause systemic toxicity.
Storage conditions
Store in a cool and dry place, protected from light. Keep out of reach of children.
Chemical structure
Atropine Sulphate 1% eye prep