Bacitracin Zinc + Polymixin B Eye prep

Bacitracin Zinc + Polymixin B Eye prep is a combination of two antibiotics: Bacitracin and Polymyxin B. Bacitracin inhibits bacterial cell wall synthesis and is active against gram-positive bacteria. Polymyxin B disrupts the bacterial cytoplasmic membrane of most gram-negative organisms. This combination provides broad-spectrum antibacterial activity.

Apply ½ inch ribbon of ointment to the affected eye(s). For acute infections: every 3-4 hours; for mild-to-moderate infections: 2-3 times daily for 7-10 days. Continue treatment for another 2 days after the eye has apparently recovered.

• Bacterial eye infections (conjunctivitis, blepharitis)
• Prevention of post-surgical eye infections

Bacitracin inhibits bacterial cell wall peptidoglycan synthesis and is active against gram-positive bacteria (staphylococci, streptococci, corynebacteria, clostridia) and some gram-negative species (Neisseria and Haemophilus influenzae).

Polymyxin B binds to membrane phospholipids, disrupting the bacterial cytoplasmic membrane of most gram-negative organisms, allowing leakage of intracellular constituents.

Bacitracin inhibits bacterial cell wall peptidoglycan synthesis. Polymyxin B disrupts the bacterial cytoplasmic membrane. This combination provides broad-spectrum activity against both gram-positive and gram-negative bacteria.

Adults and Children:

• Acute infections: Apply ½ inch ribbon to affected eye(s) every 3-4 hours for 7-10 days
• Mild-to-moderate infections: Apply ½ inch ribbon to affected eye(s) 2-3 times daily for 7-10 days
• Continue treatment for another 2 days after the eye has apparently recovered

For ophthalmic use only. Clean the affected area gently before application. Apply ½ inch ribbon of ointment to the conjunctival sac. Do not touch the dropper tip to the eye or any surface. Ointment may blur vision temporarily.

If you miss a dose, apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

• Allergic contact dermatitis (<1%)
• Conjunctival erythema
• Swelling
• Itching
• Burning

• Ointment may blur vision temporarily
• Prolonged use may cause overgrowth of non-susceptible organisms, including fungi
• Consult doctor before use if wearing contact lenses
• Caution during pregnancy and lactation

• Hypersensitivity to bacitracin, polymyxin B, or any component

• Bacitracin Zinc: Increased nephrotoxicity risk with other nephrotoxic drugs; may enhance neuromuscular-blocking agents
• Polymyxin B: Additive neurotoxic or nephrotoxic effects with bacitracin, streptomycin, neomycin, gentamicin, tobramycin, amikacin, colistin; increased risk of respiratory paralysis with neuromuscular blockers

No food restrictions (topical application).

[CONSULT YOUR DOCTOR] Limited safety data during pregnancy (Category C). Use only if clearly needed and under medical supervision.

[CONSULT YOUR DOCTOR] Excretion in breast milk is unknown. Use with caution in nursing mothers.

Pediatric dosage is same as adults. Consult doctor before use in neonates.

No dose adjustment needed for elderly patients.

Systemic absorption with topical application is minimal, but caution is advised in severe renal or hepatic impairment.

Overuse may cause systemic absorption and toxicity. Consult a doctor if symptoms occur.

Store in a cool and dry place, protected from light. Keep out of reach of children.

Bacitracin Zinc + Polymyxin B Sulphate