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Generic

Benzocaine + Oxytetracycline + Polymyxin B Eye prep

1 brands available in the market

At a glance

Benzocaine + Oxytetracycline + Polymyxin B Eye prep is a combination ophthalmic preparation used for the treatment of bacterial eye infections and corneal inflammation.

Description

Benzocaine + Oxytetracycline + Polymyxin B is a combination eye preparation containing three active ingredients that work synergistically. Benzocaine is a local anesthetic that prevents the generation and transmission of impulses along nerve fibers. Oxytetracycline is a broad-spectrum antibiotic that binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Polymyxin B disrupts the bacterial cytoplasmic membrane of most gram-negative organisms.

Eye drops: 1-2 drops 2-4 times daily.

Indications
  • Bacterial eye infections
  • Inflammation of the Cornea
Therapeutic class

Ophthalmic Antibiotic Combination

Pharmacological class

Local Anesthetic + Antibiotic + Polymyxin

Pharmacology

Benzocaine is a local anesthetic that prevents the generation and transmission of impulses along nerve fibers and at nerve endings. Depolarization and ion-exchange are inhibited. In general, loss of pain occurs before loss of sensory, autonomic and motor functions.

Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.

Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gram-negative organisms by binding to membrane phospholipids, allowing leakage of intracellular constituents.

Mechanism of action

Benzocaine blocks sodium channels in nerve cells, reducing pain sensation. Oxytetracycline inhibits bacterial protein synthesis, stopping bacterial growth. Polymyxin B disrupts the cell membrane of gram-negative bacteria. Together, they provide effective treatment against infections.

Dosage

Eye Drops: 1-2 drops 2-4 times daily.

Administration

For ophthalmic use only. Shake well before use. Do not touch the dropper tip to the eye or any surface. Keep eyes closed for 1-2 minutes after application. If using other eye drops, maintain 5-10 minutes gap.

Missed dose

If you miss a dose, apply as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Side effects
  • Local sensitivity
  • Lid itching
  • Swelling
  • Conjunctival erythema

Rare: Allergic reactions

Precautions & warnings
  • Prolonged use may cause overgrowth of non-susceptible organisms
  • Avoid use with perforated eardrum
  • Avoid if allergic to any component
  • Consult doctor before use if wearing contact lenses
Contraindications
  • Hypersensitivity to benzocaine, oxytetracycline, polymyxin B, or any component
Drug interactions

No significant drug interactions are known. Consult your doctor before using with other eye drops.

Food interactions

No food-related restrictions (eye drops).

Use in pregnancy

[CONSULT YOUR DOCTOR] Limited safety data during pregnancy. Use only if clearly needed and under medical supervision.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Use in lactation

[CONSULT YOUR DOCTOR] Excretion in breast milk is unknown. Use with caution in nursing mothers.

Pediatric use

Pediatric dosage is same as adults (1-2 drops 2-4 times daily). Consult doctor before use in neonatal eye infections.

Geriatric use

No dose adjustment needed for elderly patients.

Renal / hepatic impairment

Systemic absorption with topical ophthalmic application is minimal, but caution is advised in severe renal or hepatic impairment.

Overdose effects

Overuse may cause local irritation or allergic reactions. Consult a doctor if symptoms occur.

Storage conditions

Store in a cool and dry place, protected from light. Keep out of reach of children.

Chemical structure

Benzocaine + Oxytetracycline + Polymyxin B

Common questions

What is this eye drop used for?
It is used for bacterial eye infections and corneal inflammation.
How should it be used?
Apply 1-2 drops 2-4 times daily. Shake the bottle before use and do not touch the dropper tip.
What are the side effects?
Local sensitivity, lid itching, swelling, and conjunctival redness may occur.
Can it be used during pregnancy?
Consult your doctor before use during pregnancy.
Who should not use this medicine?
Patients allergic to any component should not use it.
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.