Betamethasone 0.1% + Clotrimazole 1% Topical

Betamethasone 0.1% + Clotrimazole 1% Topical is a combination of two medicines: Betamethasone and Clotrimazole. Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation. Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane, causing loss of essential intracellular components by altering cell wall permeability.

This cream is applied to the affected area twice daily. It is used for 2 weeks for tinea corporis and tinea cruris, and 4 weeks for tinea pedis.

• Tinea pedis
• Tinea cruris
• Tinea corporis
• Allergic or inflammatory skin diseases

Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.

Clotrimazole is a broad-spectrum antifungal agent used for the treatment of superficial infections caused by species of pathogenic dermatophytes, yeasts and Malassezia furfur. The mechanism of action involves inhibition of the synthesis of ergosterol, a major sterol in the fungal cell membrane. This leads to instability of the cell membrane and eventual death of the fungus.

Betamethasone prevents and reduces inflammation by depressing the migration of polymorphonuclear leukocytes and fibroblasts; reversing capillary permeability and lysosomal stabilisation at the cellular level. Clotrimazole binds to phospholipids in the fungal cell membrane, altering cell wall permeability and causing loss of essential intracellular components.

Adults: Apply a thin layer to the affected area twice daily (every 12 hours).

• Tinea corporis and tinea cruris: Up to 2 weeks
• Tinea pedis: Up to 4 weeks

Children (under 17 years): Safety and efficacy have not been established.

For external use only. Use in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying. Avoid contact with eyes, mouth, or vagina.

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose.

• Application site burning, itching, redness
• Thinning of skin
• Skin peeling

• For use on skin only; avoid eyes, mouth, and vagina
• Do not use occlusive dressings unless directed by a doctor
• If severe irritation or allergy occurs, discontinue use
• Inform your doctor if no improvement after 2 weeks
• Caution during pregnancy and lactation

• Hypersensitivity to clotrimazole, betamethasone dipropionate, other corticosteroids or imidazoles, or any component

No significant drug interactions are known.

No food-related restrictions (topical application).

[CONSULT YOUR DOCTOR] There is inadequate evidence of safety in pregnancy. Topical corticosteroids can cause fetal abnormalities in animals. Use only if the benefit justifies the potential risk and not for large areas or long periods.

[SAFE IF PRESCRIBED] It is not known whether the components are excreted in human milk. Limited human data suggests the drug does not represent any significant risk to the baby.

Safety and efficacy in children under 17 years have not been established.

No dose adjustment needed for elderly patients, but caution is advised.

No dose adjustment needed for patients with renal or hepatic impairment, but caution is advised.

Acute overdose is unlikely and not life-threatening. Do not use for longer than prescribed.

Store below 30°C, away from light and moisture. Keep out of reach of children.

Betamethasone 0.1% + Clotrimazole 1%