Generic
Carbonyl Iron + Folic Acid + Zinc
31 brands available in the market
At a glance
Carbonyl Iron + Folic Acid + Zinc is a combination capsule used to supplement iron, folic acid, and zinc deficiencies during pregnancy and lactation. It helps prevent anemia, supports fetal neural development, and strengthens the immune system.
Description
Carbonyl Iron + Folic Acid + Zinc is a combination capsule used to supplement iron, folic acid, and zinc deficiencies during pregnancy and lactation. It contains carbonyl iron (with high bioavailability and low toxicity), folic acid, and zinc.
Iron is an essential component in hemoglobin formation and transports oxygen. Folic acid is required for nucleoprotein synthesis and normal erythropoiesis, and helps prevent neural tube defects. Zinc is a cofactor in over 100 enzymes, plays a role in DNA synthesis, and supports a healthy immune system.
Indications
- Iron, folic acid, and zinc deficiency during pregnancy
- Iron, folic acid, and zinc deficiency during lactation
- Iron deficiency anemia
- Megaloblastic anemia due to folic acid deficiency
Therapeutic class
Iron & Vitamin Combined preparations
Pharmacological class
Iron + Folic Acid + Zinc Supplement
Pharmacology
Iron replaces iron stores found in hemoglobin, myoglobin, and enzymes, and works to transport oxygen via hemoglobin. Folic acid is converted to tetrahydrofolic acid by dihydrofolate reductase, which is required for nucleoprotein synthesis. Zinc is a cofactor in over 100 enzymes, plays a role in DNA synthesis, supports immune function, and helps maintain sense of smell and taste.
Mechanism of action
Iron supports hemoglobin formation and oxygen transport. Folic acid is required for red blood cell production and DNA synthesis. Zinc acts as a cofactor in enzymatic reactions and strengthens the immune system.
Dosage
Adults: One capsule daily. In more severe cases, 2 capsules a day may be required, or as directed by the physician.
Note: For maximum absorption, take on an empty stomach; may take with or after meals to minimize GI irritation.
Administration
For maximum absorption, take on an empty stomach; may take with or after meals to minimize GI irritation. Swallow capsules whole; do not chew or crush. Follow the dose and duration as advised by your physician.
Missed dose
If you miss a dose, take it as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not double the dose.
Side effects
Iron (>10%): Constipation, diarrhea, nausea, epigastric pain, dark stools, vomiting.
Frequency Not Defined: Hemosiderosis (during long-term administration of large amounts), urine discoloration, dental stain by some formulations, heartburn.
Folic acid: Bronchospasm, erythema, malaise, pruritus, rash, slight flushing.
Zinc: Nausea/vomiting, gastric irritation, elevations of serum alkaline phosphatase, amylase, and lipase (may return to normal within 1-2 years of therapy), neurologic deterioration (rare).
Precautions & warnings
- Caution in patients who may develop iron overload (hemochromatosis, hemolytic anemia, red cell aplasia).
- Iron chelates with tetracycline, impairing absorption; maintain at least 2-3 hours gap.
- Antacids decrease iron absorption; maintain at least 2 hours gap.
- Present in breast milk; use with caution during lactation.
Contraindications
- Known hypersensitivity to any of the ingredients
- Hemolytic anemia (iron therapy is contraindicated)
Drug interactions
- Antacids: May decrease carbonyl iron absorption (maintain at least 2 hours gap).
- Tetracyclines, quinolone antibiotics: Iron reduces absorption (maintain at least 2-3 hours gap).
- Levodopa, levothyroxine, methyldopa, penicillamine: Iron may reduce absorption.
- Antiepileptics (phenobarbital, phenytoin, primidone): Folic acid may reduce plasma concentrations.
- Oral contraceptives, anti-TB drugs, alcohol, methotrexate, pyrimethamine, trimethoprim, sulphonamides: May decrease serum folate concentrations.
- Penicillamine, thiazide diuretics: May interact with zinc.
Food interactions
For maximum absorption, take on an empty stomach. Calcium-rich foods (milk, dairy) and caffeine may reduce iron absorption; maintain at least 1-2 hours gap.
Use in pregnancy
Used during pregnancy to supplement iron, folic acid, and zinc deficiencies; take as directed by your physician.
Use in lactation
Used during lactation to supplement iron, folic acid, and zinc deficiencies; take as directed by your physician.
Pediatric use
Use in children under medical supervision.
Geriatric use
Elderly patients have higher risk of constipation; ensure adequate fluid and fiber intake.
Renal / hepatic impairment
No special precautions required for patients with liver or kidney impairment, but consult your doctor.
Overdose effects
Overdose may cause iron toxicity (vomiting, diarrhea, abdominal pain, shock, coma), folic acid, and zinc overdose symptoms. Consult your doctor immediately if overdose is suspected.
Storage conditions
Do not store above 30°C. Keep away from light and moisture. Keep out of reach of children.
Chemical structure
Carbonyl Iron + Folic Acid + Zinc