Celecoxib

Celecoxib is a pain relieving medicine. It alleviates pain, redness, and swelling in conditions such as osteoarthritis, rheumatoid arthritis, and pain during menstruation. Celecoxib can be taken with or without food. You should take it regularly as advised by your doctor. Your doctor may change the dose and time between doses according to your pain level and your needs. Do not take more or use it for longer than recommended by your doctor. Some common side effects of this medicine includes abdominal pain, diarrhea, indigestion, flatulence, peripheral edema, and dizziness. If any of these side effects bother you or do not go away, you should let your doctor know. Your doctor may help with ways to reduce or prevent these symptoms by prescribing you an alternative medicine or by adjusting the dose. The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, and liver. You should avoid consumption of alcohol while on this medication. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctors before using this medicine as it can cause harmful effects to the developing baby.

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).

• Osteoarthritis
• Rheumatoid Arthritis
• Dysmenorrhea (Pain during menstruation)
• Pain Relief
• Ankylosing Spondylitis
• Juvenile Idiopathic Arthritis

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.

Adult Dose (Oral):

Pediatric Dose: Juvenile Idiopathic Arthritis (>2 years, 10-25 kg): 100 mg twice daily.

Hepatic Dose: Moderate (Child-Pugh B): Reduce dose by 50%. Severe (Child-Pugh C or ≥10 score): Contraindicated.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Celecoxib may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Celecoxib, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common Side Effects:

• Stomach pain
• Diarrhea
• Flatulence
• Flu-like symptoms
• Peripheral edema
• Dizziness
• Indigestion

• [UNSAFE] Celecoxib may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
• Celecoxib helps relieve pain and inflammation. It may cause fewer stomach problems as compared to other NSAIDs like Ibuprofen or Naproxen.
• It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
• Do not consume alcohol while on treatment with this medicine as it may cause excessive drowsiness.
• Regularly monitor your blood pressure while taking this medicine, particularly in the first two weeks after starting treatment.
• Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
• During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function.
• Do not take Celecoxib if you are pregnant, planning to conceive, or breastfeeding.

• Hypersensitivity including those in whom attacks of angioedema, rhinitis and urticaria have been precipitated by aspirin, NSAIDs or sulfonamides.
• Severe hepatic impairment
• Severe heart failure
• Inflammatory bowel disease
• Peptic ulcer
• Renal impairment (creatinine clearance <30 mL/min)
• Pregnancy and lactation

May increase plasma level with CYP2C9 isoenzymes (e.g. fluconazole). May increase serum level of lithium. May reduce effect of antihypertensives and diuretics. May increase anticoagulant effect of warfarin.

[UNSAFE] It is unsafe to consume alcohol with Celecoxib.

[CONSULT YOUR DOCTOR] Celecoxib is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. Pregnancy Category D.

[SAFE IF PRESCRIBED] Celecoxib is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Pediatric dose: Juvenile Idiopathic Arthritis (>2 years, 10-25 kg): 100 mg twice daily.

Limited information is available on dose adjustment for elderly patients.

[CAUTION] Celecoxib should be used with caution in patients with kidney disease. Dose adjustment of Celecoxib may be needed. Please consult your doctor. Use of Celecoxib is not recommended in patients with severe kidney disease (CrCl <30 mL/min).

[CAUTION] Celecoxib should be used with caution in patients with liver disease. Dose adjustment of Celecoxib may be needed. Please consult your doctor. Use of Celecoxib is not recommended in patients with severe liver disease. Inform your doctor and stop taking this medicine if you develop any signs of liver toxicity.

Information on Celecoxib overdosage is not available. In case of overdose, symptomatic and supportive treatment should be given.

Store below 30°C, protected from light and moisture. Keep out of the reach of children.

Celecoxib