Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep)

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate is a combination medicine used for the treatment of pruritus ani, haemorrhoids, anal fissure, and proctitis. Cinchocaine Hydrochloride is a local anaesthetic that prevents or diminishes nerve impulse conduction. Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects, reducing inflammation, swelling and itching. Neomycin is an aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesis. Esculin improves skin vasculature and is effective in the management of cellulitis.

• Pruritus ani
• Haemorrhoids
• Anal fissure
• Proctitis

Cinchocaine prevents or diminishes nerve impulse conduction near to the site of administration. It also has membrane-stabilising effect owing to decrease of permeability of the nerve cell to sodium ions. Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. Esculin improves skin vasculature and is effective in the management of cellulitis.

Cinchocaine prevents or diminishes nerve impulse conduction. Hydrocortisone suppresses migration of polymorphonuclear leukocytes and reverses increased capillary permeability. Neomycin binds to 30S ribosomal subunits and inhibits protein synthesis. Esculin improves skin vasculature.

Adult Dose (Ointment): Apply onto the affected area in the morning and evening and after each stool.

Adult Dose (Suppository): Insert 1 suppository in the morning and evening and after each stool.

This medicine is for external (rectal) use only. Apply a small amount onto the affected area in the morning and evening and after each stool. As suppository, insert 1 suppository in the morning and evening and after each stool.

If you miss a dose of this medicine, use it as soon as you remember. However, if it is almost time for your next application, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common Side Effects:

• Restlessness
• Excitement, nervousness
• Paraesthesias
• Dizziness
• Tinnitus
• Blurred vision
• Nausea, vomiting
• Muscle twitching, tremors
• Convulsions
• Hypotension
• Bradycardia
• Arrhythmias
• Cardiac arrest

• Elderly, debilitated patients, children, epilepsy, impaired cardiac conduction or respiratory function, shock, hepatic impairment, myasthenia gravis require caution.
• Do not rub or touch the eye while anaesthesia persists.
• Avoid application for prolonged periods and to extensive areas.
• Caution during pregnancy and lactation.

• Complete heart block
• Pyogenic infection at or near the skin
• Application to inflamed or infected tissues or to damaged skin mucosa
• Instillation into the middle ear

No significant drug interactions are known.

No food interactions have been found or established.

Limited information is available regarding use during pregnancy. Avoid application for prolonged periods and to extensive areas. Consult your doctor.

Limited information is available regarding use during breastfeeding. Consult your doctor before use.

Limited information is available regarding use in children. Use with caution.

Use with caution in elderly patients.

For topical/rectal use, no dose adjustment is required in renal or hepatic impairment.

Information on overdosage is not available. Consult a physician if overdose is suspected.

Store in a cool and dry place, protected from light. Keep out of reach of children.

Cinchocaine Hydrochloride + Esculin + Hydrocortisone + Neomycin Sulphate