Generic
Cranberry Extract + D-Mannose
3 brands available in the market
At a glance
Cranberry Extract + D-Mannose is a combination supplement used for the treatment of urinary tract infections (UTI), recurrent UTI, kidney stones, dysuria, and acute & recurrent cystitis.
Description
Cranberry (Vaccinium macrocarpon) is a native North American plant commonly used for reduction in urinary tract infections (UTIs), recurrent UTI occurrence and it is also used to prevent kidney stone formation. Cranberry reduces the need for repeated antibiotic use in the treatment of recurrent urinary tract infection. Bacterial adherence to mucosal surfaces is generally considered to be the initial event in the pathogenesis of most infectious diseases due to bacteria in humans such as UTIs. D-mannose inhibits the uropathogenic bacteria (Escherichia coli) adherence and invasion of the uroepithelial cells.
Indications
- Urinary Tract Infection (UTI)
- Recurrent Urinary Tract Infection
- Kidney stones
- Dysuria (painful urination)
- Acute & Recurrent Cystitis
Therapeutic class
Herbal and Nutraceuticals
Pharmacological class
Herbal Supplement (Urinary Health)
Pharmacology
Cranberry inhibits adherence of bacteria to the lining of the urinary bladder and urethra. At higher dose it also works as a urinary antiseptic and reduces incidence of stone formation. Recent publications show as much as 65% reduction in UTI with cranberry consumption leading to reduced use of antibiotics and reduction in the number of incidences of recurrent cystitis. D-mannose inhibits the uropathogenic bacteria (Escherichia coli) adherence and invasion of the uroepithelial cells. Research suggests that supplemented D-mannose could be a promising alternative or complementary remedy especially as a prophylaxis for recurrent UTIs.
Mechanism of action
Cranberry PACs (proanthocyanidins) inhibit bacterial adhesion to the bladder and urethral walls. D-mannose prevents E. coli bacteria from adhering to uroepithelial cells, which are the primary cause of UTIs.
Dosage
Adult Dose: Take 1-3 capsules daily or as advised by the physician.
Administration
Take 1-3 capsules daily or as advised by the physician. Can be taken with or without food.
Missed dose
If you miss a dose of Cranberry Extract + D-Mannose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.
Side effects
Well tolerated in recommended dose. Occasionally diarrhea or mild gastrointestinal upset may occur at high dose.
Precautions & warnings
- Consult a physician before starting any new supplement.
- Do not exceed the recommended dose.
- No known restrictions during pregnancy or lactation, but consult your doctor before use.
Contraindications
- Hypersensitivity to Cranberry extract or D-mannose.
Drug interactions
No known interactions with antibiotics or other drugs. Cranberry enhances vitamin B12 absorption, which is useful for patients taking omeprazole.
Food interactions
Can be taken with or without food.
Use in pregnancy
No known restrictions during pregnancy. Consult your doctor before use.
Use in lactation
No known restrictions during lactation. Consult your doctor before use.
Pediatric use
Limited information is available regarding use in children. Use as advised by a physician.
Geriatric use
Limited information is available regarding dose adjustment for elderly patients.
Renal / hepatic impairment
Limited information is available regarding use in kidney or liver problems.
Overdose effects
Information on overdosage is not available. Consult a physician if overdose is suspected.
Storage conditions
Keep out of reach of children. Store in a dry place, below 30°C temperature and protected from light.
Chemical structure
Cranberry Extract + D-Mannose