Crizotinib

Crizotinib is used in the treatment of non-small cell lung cancer that is locally advanced or has spread to other areas of the body. Crizotinib should be taken with food or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, vomiting, edema (swelling), and diarrhea are some common side effects of this medicine. Some serious side effects that might occur which need doctor consultation include severe stomach pain, fever, chills, shortness of breath, fast heartbeat, partial or complete loss of vision or changes in bowel habits. Your doctor may perform some blood tests during the treatment to check for liver function. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Crizotinib is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

• Non-small cell lung cancer

Inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), and Recepteur d’Origine Nantais (RON) The gene’s expression and signaling that contribute to increased cell proliferation and survival of the tumors become activated following the expression of ALK oncogenic fusion proteins Inhibits the signaling that promotes the expression of these oncogenic fusion proteins, thereby inhibiting tumor cell proliferation

Adult Dose: Oral Adult Non-Small Cell Lung Cancer Indicated for treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test. Also indicated for metastatic NSCLC tumors that are ROS1-positive. Select patients for treatment of metastatic NSCLC based on presence of ALK or ROS1 positivity in tumor specimens. Capsule 250 mg PO q12hr Continue treatment as long as patient is deriving clinical benefit from therapy Dose Modifications Dosing interruption and/or dose reduction to 200 mg PO q12hr may be required based on safety and tolerability; decrease to 250 mg PO qDay if further reduction is needed Hepatic impairment: Caution advised Child Dose: Safety and efficacy not established Renal Dose: Renal impairment Mild-to-moderate (CrCl 30-90 mL/min): No starting dose adjustment is needed; steady-state trough concentrations in these 2 groups were similar to those with normal renal function (ie, CrCl >90 mL/min) Severe (CrCl <30 mL/min) or end-stage renal disease: Caution advised

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Crizotinib may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Crizotinib, skip it and continue with your normal schedule. Do not double the dose.

Common: • Nausea • Vomiting • Diarrhea • Constipation • Abdominal pain • Visual impairment • Dizziness • Taste change • Fatigue • Decreased appetite • Rash • Decreased white blood cell count (neutrophils)

[UNSAFE] Crizotinib may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Crizotinib helps in the treatment of non-small cell lung cancer that is locally advanced, or has spread to other areas of the body. Take it at the same time each day, with or without food. Diarrhea, nausea and vomiting may occur with Crizotinib. Stay hydrated and inform your doctor if it persists. It may cause dizziness or blurring of vision. Don't drive or do anything requiring concentration until you know how it affects you. Inform your doctor if you experience severe stomach pain, fever, chills, shortness of breath, fast heartbeat, partial or complete loss of vision or changes in bowel habits. Your doctor may want you to have regular blood tests to monitor your liver function while you are having treatment with this medicine. Do not take Crizotinib if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine.

Hypersensitivity

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Crizotinib. Please consult your doctor.

[CONSULT YOUR DOCTOR] Crizotinib is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Crizotinib is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Crizotinib should be used with caution in patients with severe kidney disease. Dose adjustment of Crizotinib may be needed. Please consult your doctor. [CAUTION] Crizotinib should be used with caution in patients with liver disease. Dose adjustment of Crizotinib may be needed. Please consult your doctor. Use of Crizotinib may not be advised in patients with the severe liver disease.

What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer. Right lung tumour cancer in upper portion In jalgaon district which oncologist is best for lung cancer. Dr Nitin Chaudhari us best oncologist I seem to have lung cancer , becoz all the symptoms are same as lung cancer. I test my blood, they suggests me that it is highly probable to lung cancer. Sir what can i do now. This is in preliminary stage Do you think that lung cancer is diagnosed from blood My father in law is a lung cancer patient.He had gone through two chemo cycles.The first one led to a significant reduction of about 50% in the tumor size.He was administered gemcitabine and carboplatin.However,the 2nd one was ineffective.Please advise as to what could be the next course of action. He was a smoker and has non-small cell carcinoma.The cancer has spread to the adrenal glands. U have to do a CT SCAN 3WKS AFTER 3RD CHEMOBased on that u make assessment of response Medicine for cure of lung cancer Hi Need to consult to face to face , Kindly consult to Ayurvedic doctor in your area Please see the attached file Doctor U will need medicines but right now priority is treating lung cancer Sir my dad has stage 4 lung cancer is there any treatment for it Sir can you advice me ayurvedic is better treatment for it No ayurvedic treatment for lung cancerIn allopathy 4 types of treatment are available Lung cancer stages and symptoms and standard treatment There are 4 stages, treatment would be according to it may be chemotherapy, radiotherapy or surgery, and targeted therapy. Symptoms could be cough, chest pain dyspnea etc.