Cyclosporine

Cyclosporine is used to prevent your body rejecting a new organ after a liver, kidney or heart transplant. It works by weakening your immune system so that your body does not attack the new organ. It can also be used to treat severe rheumatoid arthritis and a skin condition called psoriasis. The amount of Cyclosporine you take depends on your weight, medical condition and what you are taking it for. Your doctor will plan the correct dose for you. Do not change the dose without talking to your doctor. It can be taken with or without food. It is better to take it, in the same way, each time and at the same time every day to get the maximum benefit. Keep taking these tablets for as long as you have been told to, even if you feel well. Stopping treatment may increase the risk of your transplanted organ being rejected. The most common side effects of this medicine include headache, unusual growth of facial or body hair, high blood pressure, diarrhea and shaking or tremors. Because it lowers your immune system, you may also catch more infections than usual. Tell your doctor straight away if you develop an infection. For the same reason, you may be more at risk of developing some cancers, particularly of the skin. You should limit your exposure to sunlight. Before taking this medicine you should tell your doctor if you have liver or kidney problems, high blood pressure, gout (increased uric acid levels in the blood) or epilepsy. Also, tell your doctor about all other medicines you are taking as they may affect the working of the medicine. This medicine should only be used in pregnancy if it is clearly needed. However, it is not recommended while breastfeeding. You will have frequent medical tests while taking this medicine to check your blood pressure, liver and kidney function and mineral levels. The results of tests may lead to changes in your dose. Cyclosporine is an immunosuppressant. It works by suppressing your body’s immune response to help accept a newly transplanted organ (e.g., liver, kidney or heart). In rheumatoid arthritis, this immunosuppressive effect reduces inflammation (swelling) of joints and limits joint damage. In psoriasis, it works by reducing the activity of certain immune cells that cause overproduction of skin cells, thus improving scaling and redness.

• Prevention of organ rejection in transplant patients • Rheumatoid arthritis • Psoriasis

Ciclosporin is a strong immunosuppressant that acts mainly on the helper T-cells. It inhibits the activation of calcineurin and production of interleukin-2, thus reducing cell-mediated immune response.

Adult Dose: Oral Immunosuppression in organ transplantation Adult: Initially, 10-15 mg/kg/day, starting 4-12 hr before procedure and continued for 1-2 wk; usual maintenance: 2-6 mg/kg/day. Lower doses may be used when combined with other immunosuppressants. Severe atopic dermatitis Adult: Initially, 2.5 mg/kg/day, in 2 divided doses. Reduce to lowest effective dose once remission is achieved. Stop treatment if there is no sufficient improvement to max dose within 6 wk. Max: 5 mg/kg/day. Psoriasis Adult: Initially, 2.5 mg/kg/day, in 2 divided doses. Reduce to lowest effective dose once remission is achieved. Stop treatment if there is no sufficient improvement to max dose within 6 wk. Max: 5 mg/kg/day. Rheumatoid arthritis Adult: 2.5 mg/kg/day, in 2 divided doses. Treatment should continue for 6-8 wk. If response is insufficient, may increase dose gradually. Max: 4 mg/kg/day. Nephrotic syndrome Adult: 5 mg/kg daily, given in 2 divided doses. Intravenous Prophylaxis of graft rejection in bone marrow transplantation Adult: Intially, 3-5 mg/kg/day starting on the day before transplantation and continue for up to 2 wk or until oral therapy can be initiated at a maintenance of 12.5 mg/kg/day. Continue maintenance dose for at least 3-6 mth. Immunosuppression in organ transplantation Adult: Initially: 5-6 mg/kg/day as a single dose, infuse dose over 2-6 hr. Switch to an oral dosage form as soon as possible. Child Dose: Oral Nephrotic syndrome Child: 6 mg/kg daily, given in 2 divided doses.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Cyclosporine is to be taken with food.

If you miss a dose of Cyclosporine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Headache • Nausea • Vomiting • Increased hair growth • High blood pressure • Renal dysfunction • Loss of appetite • Diarrhea • Tremor

[CONSULT YOUR DOCTOR] It is not known whether Cyclosporine alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Cyclosporine is used to prevent organ rejection in transplant patients. It is also used to treat arthritis and immune disorders of the eyes, lungs, muscles, skin, nerves, and blood vessels. It may take 3 to 4 months for the medication to work. Keep taking it as prescribed. Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever or general illness. Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function. Do not stop taking Cyclosporine without talking to your doctor first.

Hypersensitivity; malignant neoplasms; uncontrolled hypertension; psoriasis; lactation.

Increased ciclosporin level by diltiazem, doxycycline, erythromycin, ketoconazole, methylprednisolone (high doses), nicardipine, verapamil, oral contraceptives. Drugs which reduce ciclosporin level are carbamazepine, isoniazid, phenobarbitone, phenytoin and rifampicin. Increased risk of convulsion when used concurrently with high-dose methylprednisolone. Potentially Fatal: Additive nephrotoxicity when used with aminoglycosides, amphotericin B, ciprofloxacin, colchicine, melphalan, co-trimoxazole and NSAIDs.

[SAFE] Consuming alcohol with Cyclosporine does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Cyclosporine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[UNSAFE] Cyclosporine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Cyclosporine should be used with caution in patients with kidney disease. Dose adjustment of Cyclosporine may be needed. Please consult your doctor. Regular monitoring of kidney function test is advised while you are taking this medicine. [CAUTION] Cyclosporine should be used with caution in patients with liver disease. Dose adjustment of Cyclosporine may be needed. Please consult your doctor. Regular monitoring of kidney function test is advised while you are taking this medicine.

Want to know the side effects of taking Psorid 100mg. Better to ask a dermatologist about this. ILD affected by Juvinle rheumatoid arthritis? After Lung transplant again may affected ILD because of arthritis? Yes ild can occur due to arthritis . Lung transplant is last procedure for uncontrollable disease. Medicines may control stmptoms Sir/Ma'am, I feel pain in the heel of both the legs especially when I get up from the bed in the morning. After walking couple of steps, it goes away. there is no bone problem reported in the Xray report. Please guide me what could be the reason? This is the test for rheumatoid arthritis Suffering from type 2 diabetes rheumatoid arthritis , asthma which medicine should I use Most of the diabetic drugs can be given in Rheumatoid arthritis and asthma patients however however steroids treatments is given many times in asthma and Rhumatoid arthritis should be given with very caution in diabetic patients if indicatedMost suitable some times are insulin injections I have joint pain in my rt wrist since 6 yrs. What are the possible reasons? It may be Tenosynovitis, or Rheumatoid arthritis or any other type of arthritis Im a psoriasis pateint. My advised to take psorid twice a day. What time should I take this pill. Post having my breakfast / dinner or pre ? After meals lunch and dinner What is gatheya. What is it solution It is supposed to be Rheumatoid Arthritis I am suffering from reactive arthrities. How to get rid of this. Is there any solution in ayurveda. I think you are talking about Rheumatoid Arthritis If yes, then please consult a Rheumatologist