Dexketoprofen

Dexketoprofen is the S(+)-enantiomer of Ketoprofen and is responsible for the analgesic and anti-inflammatory activity of Ketoprofen. The inactive R(-)-enantiomer does not contribute to the therapeutic properties of Ketoprofen but adds to the metabolic load. Dexketoprofen has been formulated as a trometamol salt, ensuring rapid absorption and onset of action.

• Musculoskeletal pain
• Menstrual pain
• Dental pain
• Pain and inflammation of mild to moderate intensity

Dexketoprofen is the S(+)-enantiomer of Ketoprofen and is responsible for the analgesic and anti-inflammatory activity of Ketoprofen. The inactive R(-)-enantiomer does not contribute to the therapeutic properties of Ketoprofen but adds to the metabolic load. Dexketoprofen has been formulated as a trometamol salt, ensuring rapid absorption and onset of action.

Dexketoprofen inhibits cyclo-oxygenase enzyme, reducing prostaglandin synthesis, thereby decreasing pain and inflammation.

Adult (Rheumatic disorders): 100-200 mg/day in 2-4 divided doses (max 300 mg/day).
Adult (Pain and inflammation): 25-50 mg every 6-8 hours (max 300 mg/day).
Elderly: Initial daily dose should not exceed 50 mg/day.
Hepatic/Renal impairment: Initial 50 mg/day; not to be used in severe impairment.

Take on an empty stomach (for acute pain, take at least 30 minutes before meals). Swallow the tablet whole, do not chew, crush or break.

If you miss a dose of Dexketoprofen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common (1-10%): Nausea, vomiting, diarrhea, stomach pain, heartburn.
Uncommon (0.1-1%): Sleep disorders, nervousness, headache, dizziness, vertigo, palpitations, constipation, dry mouth, flatulence, skin rash, fatigue, hot flushes, shivering.
Rare (0.01-0.1%): Stomach ulceration, gastric hemorrhage or perforation, hypertension, fluid retention, increased liver enzymes.
Very rare (<0.01%): Blurred vision, tinnitus, hypotension, hematological reactions, hepatic/renal damage, photosensitivity, bronchospasm, anaphylaxis.

May affect driving ability (drowsiness, dizziness, visual disturbances). Avoid alcohol (increases risk of stomach problems). Do not take antacids within 2 hours of Dexketoprofen. Caution in heart disease, stroke, peptic ulcer, liver and kidney disease.

Hypersensitivity; history of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria, angioedema with aspirin or other NSAIDs; peptic ulcer; GI bleeding history; bronchial asthma; severe heart failure, moderate-severe renal or hepatic impairment; bleeding or coagulation disorders; pregnancy and lactation.

Other NSAIDs: Increased risk of GI ulcers and bleeding.
Oral anticoagulants, heparin: Increased risk of bleeding.
Lithium: May reach toxic levels.
Methotrexate (≥15 mg/week): Increased hematological toxicity.
Hydantoins, sulfonamides, sulfonylureas, ACE inhibitors, diuretics, beta-blockers, cyclosporine, tacrolimus, zidovudine, pentoxifylline, probenecid, cardiac glycosides, mifepristone, quinolone antibiotics: May interact.

It is unsafe to consume alcohol with Dexketoprofen (increases risk of stomach problems).

Pregnancy Category C. Dexketoprofen may be unsafe during pregnancy. Use during pregnancy and lactation is not recommended.

Dexketoprofen is probably safe during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. However, use during lactation is not recommended.

Not recommended for children.

Elderly patients should start with a daily dose not exceeding 50 mg/day.

Renal impairment: Use with caution. Mild impairment: initial 50 mg/day; moderate-severe impairment: do not use.
Hepatic impairment: Use with caution. Mild-moderate impairment: initial 50 mg/day; severe impairment: do not use.

Treatment of overdose is symptomatic; no specific antidote.

Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.

Dexketoprofen