Dexketoprofen

Dexketoprofen is used for the treatment of moderate to severe pain. It helps in relieving pain, such as dental pain, muscle pain, joint pain, and pain during menstruation. Dexketoprofen should be taken with food, preferably with an adequate amount of water. This will prevent you from getting an upset stomach. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. The most common side effects of this medicine include nausea, vomiting, stomach pain, diarrhea, and indigestion. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant and breastfeeding mothers should consult their doctors before using the medicine. Dexketoprofen is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

• Pain relief

Dexketoprofen exhibits anti-inflammatory, analgesic and antipyretic properties. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.

Adult Dose: Adult: PO Rheumatic disorders 100-200 mg/day in 2-4 divided doses. Max: 300 mg/day in divided doses. Pain and inflammation 25-50 mg 6-8 hrly. Max: 300 mg/day. Elderly: Initial total daily dose should not exceed 50 mg/day. May increase to the doses recommended for general population only if well tolerated. Hepatic Impairment: Mild to moderate impairment: Reduce initial dose to 50 mg/day. Not to be used in severe hepatic impairment. Renal Dose: Mild renal impairment: Reduce initial dose to 50 mg/day. Not to be used in moderate to severe renal impairment.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dexketoprofen is to be taken empty stomach.

Common: • Vomiting • Nausea • Stomach pain • Indigestion • Heartburn

[UNSAFE] Dexketoprofen may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Dexketoprofen to relieve pain and inflammation. Take it with food or milk to prevent upset stomach. Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems. Do not take indigestion remedies (antacids) within two hours of taking Dexketoprofen. Avoid consuming alcohol while taking Dexketoprofen as it can increase your risk of stomach problems. Inform your doctor if you have a history of heart disease or stroke. Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.

Dexketoprofen tablets are not recommended to use in patients who are: - Allergic to this product or any of its components, aspirin or other non-steroidal anti-inflammatory medicines. - Have suffered attacks of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria, angioedema (swollen face, eyes, lips, or tongue, or difficulty in breathing), after taking aspirin or other non-steroidal anti-inflammatory medicines. - Have or have previously suffered from a peptic ulcer or chronic gastro-intestinal disorders. - Have had previously gastro-intestinal haemorrhage (bleeding). - Have suffered from bronchial asthma. - Have severe heart failure, moderate to severe renal dysfunction or severely impaired hepatic function. - Have a bleeding disorder, a blood clotting disorder or taking an anticoagulant. - Pregnant or breast-feeding.

Increased risk of GI ulcers & bleeding (synergistic effect) w/ other NSAIDs. Increased risk of haemorrhagic effect of oral anticoagulants. Increased risk of haemorrhage w/ heparin. Increased blood lithium levels, which may reach toxic values, w/ lithium. Increased haematological toxicity of methotrexate at high dose of ?15 mg/wk. Increased toxic effects of hydantoins & sulphonamides. Increase risk of bleeding & damage of GI mucosal w/ anticoagulant. Increase hypoglycemic effect of sulfonylurea agents.

[UNSAFE] It is unsafe to consume alcohol with Dexketoprofen.

[CONSULT YOUR DOCTOR] Dexketoprofen may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Dexketoprofen is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Dexketoprofen should be used with caution in patients with kidney disease. Dose adjustment of Dexketoprofen may be needed. Please consult your doctor. Use of Dexketoprofen is not recommended in patients with moderate to severe kidney disease. Take plenty of fluids while taking this medicine. [CAUTION] Dexketoprofen should be used with caution in patients with liver disease. Dose adjustment of Dexketoprofen may be needed. Please consult your doctor. Use of Dexketoprofen is not recommended in patients with severe liver disease.

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