Generic
Dexpanthenol
2 brands available in the market
At a glance
Dexpanthenol is a topical ointment used for the prevention and treatment of diaper rash, cracked or sore nipples in nursing mothers, dry skin, and minor wounds.
Description
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A. Dermatological effects include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties.
Indications
- Prevention and treatment of diaper rash in infants
- Prevention and treatment of cracked or sore nipples in nursing women
- Prevention and treatment of chafed, cracked or split skin
- Treatment of minor skin wounds and dry skin
Therapeutic class
Miscellaneous topical agents
Pharmacological class
Topical Ointment (Pantothenic Acid Derivative)
Pharmacology
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A. Topical use increases fibroblast proliferation and accelerates re-epithelialization in wound healing.
Mechanism of action
Dexpanthenol increases fibroblast proliferation, accelerates re-epithelialization in wound healing, maintains skin moisture, and reduces inflammation.
Dosage
Diaper rash: Apply a thin layer on the baby's bottom at every diaper change.
Nipples: Apply a thin layer on the nipples after each nursing session; wash thoroughly before the next nursing session.
Dry/cracked skin or minor wounds: Apply up to 3 times a day.
Administration
For external use only. Apply a thin layer to the affected area. Do not swallow.
Missed dose
If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.
Side effects
Rare: Allergic reaction, atopic dermatitis, allergic dermatitis, pruritus, redness, rash, eczema, urticaria, local irritation or blistering.
Precautions & warnings
For external use only. Discontinue use and consult a doctor if allergic or skin reactions occur.
Contraindications
Hypersensitivity to any component.
Drug interactions
No adequate information on drug interactions is available.
Food interactions
Can be used with or without food.
Use in pregnancy
No adequate information is available regarding use during pregnancy. Please consult your doctor.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Use in lactation
No adequate information is available regarding use during lactation. Please consult your doctor.
Pediatric use
Safe for use in pediatric patients (for diaper rash).
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
No special precautions are necessary for patients with kidney or liver problems.
Overdose effects
Do not exceed the recommended dose. Excessive use may cause skin irritation.
Storage conditions
Do not store above 30°C. Keep away from light and out of reach of children.
Chemical structure
Dexpanthenol