Difamilast

Difamilast is a PDE4 inhibitor that increases cyclic adenosine 3',5'-monophosphate (cAMP) concentration and consequently suppresses the production of inflammatory cytokines, exerting effects in the treatment of atopic dermatitis.

• Atopic dermatitis (eczema)

Difamilast is a phosphodiesterase 4 (PDE4) inhibitor. It increases cyclic adenosine 3',5'-monophosphate (cAMP) concentration and consequently suppresses the production of inflammatory cytokines, exerting effects in the treatment of atopic dermatitis.

Difamilast inhibits PDE4 enzyme, increasing cAMP levels, which suppresses inflammatory cytokine production and reduces inflammation in atopic dermatitis.

Adult: 1% ointment applied to the affected area twice daily.
Children: 0.3% ointment applied to the affected area twice daily.

For external use only. Apply a small amount of ointment to the affected area and gently massage.

If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.

Common: Well tolerated at recommended dosage. At higher dosage, mild skin reactions (redness, burning, or stinging) at the application site may occur.

For external use only. Not for oral, ophthalmic, or intravaginal use. If hypersensitivity occurs, treatment should be discontinued.

Known hypersensitivity to the drug.

No adequate information on drug interactions is available.

Can be used with or without food.

Not recommended for pregnant women or women who may possibly be pregnant.

Safety profile has not been fully established for breastfeeding.

0.3% ointment is indicated for pediatric patients.

No specific dosage adjustment is necessary for elderly patients.

No special precautions are necessary for patients with kidney or liver problems.

No adequate information on overdose is available.

Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.

Difamilast