Generic
Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertussis + Hepatitis B Vaccine
2 brands available in the market
At a glance
Diphtheria Toxoid 30IU + Tetanus Toxoid 60IU + Pertussis + Hepatitis B Vaccine is a combination vaccine used for active immunization against diphtheria, tetanus, pertussis, and hepatitis B in infants.
Description
This vaccine is used for the active immunisation of diphtheria, tetanus and pertussis in children from 6 weeks to 6 years of age. It produces specific antibodies to tetanus, diphtheria, and pertussis (active immunity) and conveys active immunity via stimulation of production of endogenously produced antibodies.
Indications
- Prevention of diphtheria, tetanus, pertussis, and hepatitis B in infants
Therapeutic class
Vaccines, Anti-sera & Immunoglobulin
Pharmacological class
Combination Vaccine
Pharmacology
This vaccine is used for the active immunisation of diphtheria, tetanus and pertussis in children from 6 weeks to 6 years of age. It produces specific antibodies to tetanus, diphtheria, and pertussis.
Mechanism of action
The vaccine stimulates the production of specific antibodies against diphtheria, tetanus, pertussis, and hepatitis B by introducing antigens and triggering an immune response.
Dosage
Child (Primary Immunization): 3 doses of 0.5 mL deep IM injection within the first 6 months of life at intervals of at least 4 weeks.
Booster dose: Administer during the 2nd year of life.
Administration
Administer as a deep intramuscular injection (antero-lateral thigh in infants).
Missed dose
The vaccine is administered by healthcare professionals. You cannot miss a dose yourself.
Side effects
Common (>10%): Irritability/fussiness (61-65%), drowsiness (41-57%), fever (28-39%), loss of appetite (26-31%), swelling (17-29%).
Occasional (1-10%): Fever (≤1%).
Rare (<1%): Anorexia, apnea, erythema, decreased consciousness, diarrhea, hypotonia, encephalitis, brachial neuritis, peripheral neuropathy, cough, lethargy, limb pain, liver function test abnormalities, rash, restlessness.
Precautions & warnings
Previous reaction to DTP vaccine; family history of convulsions, SIDS; bleeding disorders; immunosuppression/deficiency; pregnancy, lactation. Postpone vaccination in acute severe febrile illness. Administer SC in patients with thrombocytopenia or bleeding disorders. Risk of apnea.
Contraindications
Previous encephalopathy after pertussis vaccine; acute severe febrile illness; hypersensitivity to any component; history of encephalopathy of unknown etiology occurring within 7 days following previous vaccination; do not administer IV.
Drug interactions
No adequate information on drug interactions is available.
Food interactions
Can be used with or without food.
Use in pregnancy
Pregnancy Category C.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Not indicated for women of childbearing age.
Pediatric use
Indicated for children from 6 weeks to 6 years of age.
Geriatric use
Not indicated for elderly patients.
Renal / hepatic impairment
No special precautions are necessary for patients with kidney or liver problems.
Overdose effects
No adequate information on overdose is available.
Storage conditions
Store at 2-8°C in a refrigerator. Do not freeze. Protect from light.
Chemical structure
Diphtheria Toxoid + Tetanus Toxoid + Pertussis + Hepatitis B Vaccine