Domperidone

Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.

• Dyspeptic symptom complex (fullness, bloating, heartburn)
• Nausea and vomiting
• Non-ulcer dyspepsia
• Dopamine-agonist-induced nausea and vomiting in Parkinson's disease

Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the Chemoreceptor Trigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of the gastrointestinal tract.

Domperidone blocks dopamine receptors in the CTZ to control vomiting and increases gastric motility to facilitate food movement.

Adult (Nausea/Vomiting): 10-20 mg every 4-8 hours (max 80 mg/day).
Adult (Dyspepsia): 10 mg 3-4 times daily (max 20 mg 3-4 times daily, last dose at bedtime).
Child: 0.2-0.4 mg/kg every 4-8 hours.

Take 15-30 minutes before meals. Swallow the tablet whole, do not chew, crush or break.

If you miss a dose of Domperidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common: Headache, dry mouth, stomach pain, diarrhea.
Rare: Transient intestinal cramps, extrapyramidal reactions (in children), hyperprolactinemia (galactorrhea, gynecomastia), allergic reactions.

May affect driving ability (drowsiness, dizziness). Avoid alcohol. Do not use in GI hemorrhage, obstruction, or perforation. Do not use for longer than 7 days without consulting your doctor. Caution in liver and kidney disease.

Hypersensitivity; GI hemorrhage, obstruction, and perforation; prolactin-releasing pituitary tumor (prolactinoma); neonates.

Anticholinergic drugs: Antagonize the antidyspeptic effect.
Antacids and antisecretory drugs: Reduce oral bioavailability when given simultaneously.
CYP3A4 inhibitors (ketoconazole, erythromycin, ritonavir): Increased serum levels and risk of QT prolongation.
Bromocriptine: Antagonizes hypoprolactinaemic effect.
Opioid analgesics, antimuscarinics: Antagonize prokinetic effect.

It is not known whether it is safe to consume alcohol with Domperidone. Please consult your doctor.

Pregnancy Category C. Use during pregnancy only if clearly needed and under medical advice.

Domperidone is excreted in breast milk; caution is required during lactation.

Children: 0.2-0.4 mg/kg every 4-8 hours; caution in infants under 1 year.

No dosage adjustment is necessary for elderly patients.

Renal impairment: Use with caution; reduce dosing frequency to 1-2 times daily in severe renal impairment.
Hepatic impairment: Use with caution; not recommended in moderate to severe liver disease.

Overdose may cause drowsiness, disorientation, extrapyramidal reactions (especially in children); activated charcoal and observation; anticholinergic drugs may be helpful.

Keep below 30°C temperature, away from light & moisture.

Domperidone