Ebastine

Ebastine is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H1 receptors. It is indicated for symptomatic treatment of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. It is metabolised to active metabolite carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. Dose: 10-20 mg once daily for adults, 5 mg once daily for children 6-12 years. Common side effects include headache, dry mouth and drowsiness.

• Seasonal allergic rhinitis
• Perennial allergic rhinitis
• Chronic idiopathic urticaria

Ebastine is a long-acting and selective H1-histamine receptor antagonist. After repeated administration, inhibition of peripheral receptors remains at a constant level. Ebastine is rapidly absorbed and undergoes extensive first-pass metabolism following oral administration. It is almost totally converted to the pharmacologically active acid metabolite, carebastine.

Ebastine binds preferentially to peripheral H1 receptors. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.

Adult Dose (>12 years): 10-20 mg once daily.

Child Dose (6-12 years): 5 mg (half tablet) once daily.

Child Dose (2-5 years, syrup): 2.5 ml once daily (up to 5 ml in severe cases).

Child Dose (6-12 years, syrup): 5 ml once daily (up to 10 ml in severe cases).

Oral tablet or syrup. Take in the dose and duration as advised by your doctor. Swallow whole. Do not chew, crush or break. May be taken with or without food, but better to take at a fixed time.

If you miss a dose of Ebastine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common Side Effects:

• Headache
• Dry mouth
• Drowsiness
• Abdominal pain
• Dyspepsia
• Nausea
• Insomnia

• Ebastine helps relieve allergy symptoms such as itching, swelling, and rashes.
• As compared to other similar medications, it is much less likely to make you feel sleepy.
• Be cautious while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
• Do not drink alcohol while taking this medication (may cause increased sleepiness).
• Stop taking Ebastine at least three days before taking an allergy test (can affect test results).

• Hypersensitivity
• Cardiac arrhythmias

Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation.

Ebastine may cause excessive drowsiness with alcohol.

Information regarding the use of Ebastine during pregnancy is not available. Please consult your doctor.

Information regarding the use of Ebastine during breastfeeding is not available. Please consult your doctor.

Can be used in children >2 years in syrup form. Tablet for children 6-12 years.

Limited information available regarding dose adjustment for elderly patients.

Renal impairment: Limited information available on use in kidney disease. Consult your doctor.

Hepatic impairment: Limited information available on use in liver disease. Consult your doctor.

No clinically meaningful signs or symptoms observed up to 100 mg once daily. No specific antidote. Gastric lavage, ECG monitoring and symptomatic treatment.

Store below 30°C at a cool and dry place, away from light. Keep out of reach of children.

Ebastine