Ertapenem

Ertapenem is an antibiotic belonging to the carbapenem group that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (eg. meningitis). It works by killing the bacteria that cause these problems. Ertapenem is commonly used to treat seriously ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like headache, vomiting, nausea, diarrhea, rash or local redness and swelling at the site of injection. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Before starting treatment with this medicine, you should tell your doctor if you have epilepsy, liver or kidney problems or if you are allergic to any antibiotic. While using it, you may be advised blood tests to monitor your blood cell counts and kidney function. This medicine is generally regarded as safe to use in pregnancy and breastfeeding if prescribed by your doctor. Ertapenem is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Bacterial infections

Ertapenem acts similarly to penicillins by bacterial cell wall inhibition. It is active against many gram-negative and aerobic and anaerobic organisms. It is stable to hydrolysis by beta-lactamases.

Adult Dose: Community-Acquired Pneumonia 1 g/day IV/IM up to 14 days; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically Complicated Urinary Tract Infections (Including Pyelonephritis) 1 g/day IV/IM up to 14 days; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically Acute Pelvic Infections 1 g/day IV/IM for 3-10 days Complicated Intra-abdominal Infections 1 g/day IV/IM for 5-14 days Complicated Skin/Skin Structure Infections 1 g/day IV/IM for 7-14 days; may be continued up to 4 weeks for diabetic foot infections, depending on severity of infection and response to therapy (treatment excludes diabetic foot infections with osteomyelitis) Child Dose: Community-Acquired Pneumonia, Complicated Urinary Tract Infections (Including Pyelonephritis) 3-12 years: 15 mg/kg IV/IM q12hr up to 14 days; not to exceed 1 g q12hr; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically >12 years: 1 g/day IV/IM up to 14 days; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically Complicated Intra-abdominal Infections, Complicated Skin/Skin Structure Infections 3-12 years: 15 mg IV/IM q12hr for 7-14 days >12 years: 1 g/day IV/IM for 7-14 days <3 years: Safety and efficacy not established Renal Dose: Renal impairment CrCl >30 mL/min/1.73 m²: Dosage adjustment not necessary CrCl <30 mL/min/1.73 m² and end-stage renal disease (ESRD): 500 mg/day IV Dialysis: 500 mg/day IV; if given ?6 hr before dialysis, supplemental dose of 150 mg afterward

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Ertapenem, please consult your doctor.

Common: • Injection site reactions (pain, swelling, redness) • Vomiting • Nausea

[UNSAFE] Ertapenem may cause side effects which could affect your ability to drive. Certain side effects, such as dizziness and sleepiness, have been reported with Ertapenem, which may affect some patients’ ability to drive or operate machinery Ertapenem is an antibiotic that's usually only given in the hospital for serious infections. It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes. Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication. Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools. Your doctor may monitor your liver and kidney function while you are having treatment with this medication.

Hypersensitivity; lactation.

May decrease plasma levels of valproic acid thus, increasing the risk of seizures. Increased plasma concentrations w/ probenecid.

[SAFE] Consuming alcohol with Ertapenem does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Ertapenem is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Ertapenem is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Ertapenem should be used with caution in patients with kidney disease. Dose adjustment of Ertapenem may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Ertapenem is safe to use in patients with liver disease. No dose adjustment of Ertapenem is recommended.

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