Erythropoietin

Erythropoietin is a medicine that helps your bone marrow to produce more red blood cells. It is used to treat a type of anemia caused by kidney disease. It is also used to treat anemia caused by cancer chemotherapy and by taking medicines to treat HIV. Erythropoietin is given by injection either under the skin or into a vein which will be decided by your doctor. Usually the injections are given by a nurse or doctor. The dose depends on your body weight and the cause of your anemia. Iron supplements both before and during treatment may make this treatment more effective. Erythropoietin needs to be stored in a fridge but used at room temperature. The most common side effects of taking this medicine include nausea, vomiting and increased blood pressure. It may also cause flu-like symptoms such as headache, tiredness, dizziness and aches and pains. These side effects are most common at the start of treatment but if they persist your doctor may be able to suggest ways of preventing or reducing them. Tell your doctor straight away if you get any serious side effects, including seizures (fits). Sometimes this medicine can cause serious blood clots which need urgent medical attention. Before using Erythropoietin you should tell your doctor if you have uncontrolled high blood pressure, heart disease or gout (disease of joint pain). You should also tell him/her what other medicines you are taking in case they affect this treatment. Your blood pressure should be checked often during this treatment by you or your doctor. You may also need other regular medical tests to be sure this medicine is not causing harmful effects. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding. Erythropoietin is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.

• Anemia due to chronic kidney disease • Anemia due to cancer chemotherapy

Erythropoietin regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors, stimulating the release of reticulocytes into the circulation, and synthesis of cellular haemoglobin. Recombinant human erythropoietin is available as epoetin alfa and epoetin beta which are used in the management of anaemias associated with CRF, cancer chemotherapy and anti-AIDS drug zidovudine.

Adult Dose: Chronic Kidney Disease-Associated Anemia Reduction of need for red blood cell (RBC) transfusion in patients with chronic kidney disease (CKD) Patient not on dialysis: 50-100 units/kg IV/SC 3 times weekly initially Initiate only when (1) hemoglobin level 10 g/dL, reduce or interrupt dose and use lowest dose sufficient to reduce need for RBC transfusion Patient on dialysis: 50-100 units/kg IV 3 times weekly initially Initiate when hemoglobin level 2 months 150 units/kg IV/SC 3 times weekly initially; alternatively, 40,000 units SC once weekly until completion of chemotherapy course Preparation for Surgery With High Risk of Blood Loss Reduction of need for allogeneic RBC transfusions in patients with perioperative hemoglobin >10 g/dL but ?13 g/dL who are at high risk for perioperative blood loss from elective, noncardiac, nonvascular surgery 300 units/kg SC once daily for 15 consecutive days (10 days preceding surgery, day of surgery, 4 days following surgery); alternatively, 600 units/kg SC in 4 doses administered 21, 14, and 7 days before surgery and on day of surgery Child Dose: Chronic Kidney Disease-Associated Anemia 1 month: 50 units/kg IV/SC 3 times weekly initially; if patient on dialysis, IV route recommended Initiate when hemoglobin level <10 g/dL; if hemoglobin level approaches or exceeds 11 g/dL, reduce or interrupt dose Prematurity-Related Anemia 25-100 units/kg SC 3 times weekly or 200-400 units/kg SC/IV q24-48hr for 2-6 weeks Zidovudine-Related Anemia <8 months: Safety and efficacy not established 8 months-17 years: 50-400 units/kg SC/IV 2-3 times weekly Chemotherapy-Related Anemia <5 years: Safety and efficacy not established 5-18 years: 600 units/kg IV once weekly; not to exceed 40,000 units

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Erythropoietin, please consult your doctor.

Common: • High blood pressure • Nausea • Fever • Vomiting

[UNSAFE] Erythropoietin may cause side effects which could affect your ability to drive. Erythropoietin helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy. It is given as a single injection under your skin. Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin, blood cells and electrolytes such as potassium in your blood. Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting or fits (seizures). Stop taking Erythropoietin and inform your doctor if you develop shortness of breath or skin rash.

Uncontrolled hypertension, hypersensitivity to mammalian cell products and human albumin.

Haematinics enhance efficiency. Increased dose of heparin in patients undergoing dialysis.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Erythropoietin. Please consult your doctor.

[CONSULT YOUR DOCTOR] Erythropoietin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Erythropoietin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Erythropoietin is safe to use in patients with kidney disease. No dose adjustment of Erythropoietin is recommended. Regular monitoring of kidney function tests is advised while the patient is taking this medicine. [CAUTION] Erythropoietin should be used with caution in patients with liver disease. Dose adjustment of Erythropoietin may be needed. Please consult your doctor.

Blood Hb is found 5.9 so wat is it Dear PATIENT from 1mg. The hemoglobin is very low, which can be due to anemia. I suggest you should consult a Hematologist /Physician for this. how to resolve the problem of anemia? Intake of dates and jaggery will help Submucouse fibrosis and unable to open mouth It is usually due to chronic tobacco chewing. If you are taking stop. Takes long time to improve. May become cancer later on. Can use hyalase and kenacort injection locally. Improve in few patients. It it very severe may need surgery Iron deficiency anemia, typhoid What medicine u taking for thatSince when u have these problem Weight loss is a challenge despite active lifestyle. Water retention. One kidney not functional. Anemia, hb 9.2. eat 6-7 meals per day, which consist fruits, nuts, buttermilk,sprouts,idly,curd eggs,sprouts homecooked food. Drink 3-4 litters of water limit your sugar consumption to 2 spoon per day. Be active whole day for personalized diet chart write to me on do minimum 45 min exercise everyday like yoga, cardioare u taking treatment for kidney, if yes then consult dietician where u are going for treatment because it should be planned under doctor&#x27;s guidance Please check and advise my blood reports Dear Sir Greetings from 1mg. The reports shows a low hemoglobin level which can be due to iron deficiency anemia. Have a diet rich in lots of iron like leafy vegetables, fruits etc. Why cramps comming in leg basically It may be because of many reasons Weak bones, weak muscles, anemia, DVT, thyroid disease etc I am so much of pain in my back side &and so tideness of my body Consult a physician. Get your Hb checked to rule out anemia.