Esomeprazole + Amoxicillin + Clarithromycin Kit

This kit contains three medicines: Amoxicillin, Clarithromycin and Esomeprazole. Amoxicillin destroys bacteria by inhibiting cell wall synthesis. Clarithromycin stops bacterial growth by inhibiting protein synthesis. Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production and relieves acid-related indigestion and heartburn.

Peptic ulcer disease (active chronic gastric, duodenal and gastric ulcers caused by H. pylori infection).

Anti-H. pylori drugs

Antibiotic + Proton Pump Inhibitor

Esomeprazole irreversibly inhibits H+/K+ ATPase enzyme in gastric parietal cells to suppress gastric acid secretion. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Clarithromycin inhibits protein synthesis by binding to the 50S ribosomal subunit.

Amoxicillin inhibits bacterial cell wall synthesis. Clarithromycin inhibits bacterial protein synthesis. Esomeprazole reduces gastric acid production. Together, these three medicines eradicate H. pylori infection and heal ulcers.

Twice daily (morning and evening) for 7-14 days. Each strip contains 1 Esomeprazole 20mg capsule, 2 Amoxicillin 500mg tablets and 1 Clarithromycin 500mg tablet.

Take on an empty stomach. Swallow tablets and capsules whole; do not chew or crush. Take at a fixed time each day.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Common side effects: Diarrhea, nausea, vomiting, stomach pain, taste change, flatulence, headache, rash. Serious side effects: Allergic reactions (rash, itching, swelling of face, breathing difficulty).

Unsafe during pregnancy. Caution during lactation. Dose adjustment may be needed in kidney disease. Safe in liver disease. Avoid alcohol. Caution while driving.

Hypersensitivity to any component. Allergy to penicillin or macrolide antibiotics.

Esomeprazole is metabolized through the cytochrome P450 system, especially CYP3A isozymes. Clarithromycin may increase serum theophylline levels. Interactions reported with carbamazepine, cyclosporine, tacrolimus, phenytoin, lovastatin, cisapride, pimozide and astemizole.

Caution advised when consuming alcohol as it may increase drowsiness and dizziness.

Use during pregnancy only if clearly needed. Animal studies have shown harmful effects on the fetus.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Safe during breastfeeding. Does not pass into breast milk in significant amounts.

Safety and efficacy not established in children.

No dose adjustment necessary for elderly patients.

Use with caution in kidney disease; dose adjustment may be needed. Safe in liver disease; no dose adjustment needed.

Limited information on overdose. May cause diarrhea, nausea and stomach pain.

Store below 30°C in a cool and dry place. Keep out of reach of children.

Esomeprazole 20mg + Amoxicillin 500mg + Clarithromycin 500mg