Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection. Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is a prescription medicine and it is to be taken it as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve. Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help. Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body. Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is a combination of four medicines: Isoniazid, rifampicin, ethambutol and pyrazinamide which treat tuberculosis. Isoniazid works by preventing the TB bacteria from forming their own protective covering, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol and pyrazinamide on the other hand, work by slowing the growth of these bacteria.

• Tuberculosis (TB)

Rifampicin, isoniazid and pyrazinamide are all active bactericidal antituberculosis drugs. Rifampicin and isoniazid are particularly active against the rapidly growing extracellular organisms and have an intracellular bactericidal activity. Rifampicin also inhibits DNA-dependent RNA polymerase activity in susceptible cells and it has activity against slow and intermittently-growing M tuberculosis. Pyrazinamide, particularly in the acid pH environment of macrophages is active against intracellular organisms. Combination of these agents covers activity against the 3 different bacterial populations. Ethambutol interferes with RNA synthesis, causing suppression of Mycobacteria multiplication. It also has bacteriostatic action against M tuberculosis by acting on rapidly growing pathogens in cavity walls and is also effective in slow-growing pathogens. Has some action against atypical opportunistic Mycobacteria e.g. M kansasii, M avium complex (MAC).

Adult Dose: Fixed-dose combinations (FDCs) Tablets Rifampicin 150mg + Isoniazid 75mg + Pyrazinamide 400mg + Ethambutol 275mg (4FDC) New patients: Body weight 30-37kg: Initial 2 months- 4-FDC 2 tablets at a time daily; next 4 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 2 tablets at a time daily. 38-54kg: Initial 2 months- 4-FDC 3 tablets at a time daily; next 4 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 3 tablets at a time daily. 55-70kg: Initial 2 months- 4-FDC 4 tablets at a time daily; next 4 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 4 tablets at a time daily. >70kg: Initial 2 months- 4-FDC 5 tablets at a time daily; next 4 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 5 tablets at a time daily. Re-treatment patients: Body weight 30-37kg: Initial 3 months- 4-FDC 2 tablets at a time daily; & Streptomycin 500mg daily, next 5 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 2 tablets at a time daily, & Ethambutol 400mg 2 tablets at a time daily. 38-54kg: Initial 3 months- 4-FDC 3 tablets at a time daily; & Streptomycin 750mg daily, next 5 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 3 tablets at a time daily, & Ethambutol 400mg 3 tablets at a time daily. 55-70kg: Initial 3 months- 4-FDC 4 tablets at a time daily; & Streptomycin 1g daily, next 5 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 4 tablets at a time daily, & Ethambutol 400mg 3 tablets at a time daily. >70kg: Initial 3 months- 4-FDC 5 tablets at a time daily; & Streptomycin 1g daily, next 5 months- continuation dose 2-FDC (Rifampicin 600mg + Isoniazid 300mg) 5 tablets at a time daily, & Ethambutol 400mg 4 tablets at a time daily. The dose of streptomycin should not exceed 750mg daily after the age of 50 years.

Take this medicine in the dose and duration as advised by your doctor. Check the label before use. Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is to be taken empty stomach. Avoid Ethambutol + Isoniazid + Pyrazinamide + Rifampicin with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Common: • Nausea • Vomiting • Rash • Fever • Dark colored urine • Sweating • Increased sputum production • Salivation • Watery eyes • Peripheral neuropathy (tingling and numbness of feet and hand) • Increased liver enzymes • Jaundice • Increased uric acid level in blood • Visual impairment

[UNSAFE] Ethambutol + Isoniazid + Pyrazinamide + Rifampicin may cause side effects which could affect your ability to drive. Ethambutol + Isoniazid + Pyrazinamide + Rifampicin occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you. You have been prescribed Ethambutol + Isoniazid + Pyrazinamide + Rifampicin for the treatment of tuberculosis. Take it on an empty stomach and preferably at the same time everyday. Try not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects. It may discolour your urine, sweat, saliva and tears a reddish/orange colour. This is normal and not harmful. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Avoid drinking alcohol while taking Ethambutol + Isoniazid + Pyrazinamide + Rifampicin as this may increase the risk of side effects on the liver. It may cause vitamin B6 deficiency. Your doctor may prescribe vitamin B6 supplements to help avoid potential problems associated with its deficiency, such as inflammation of the nerves (neuritis). Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Ethambutol + Isoniazid + Pyrazinamide + Rifampicin as it may make hormonal contraceptives such as the pill less effective. Do not take indigestion remedies (antacids) within at least two hours of taking Ethambutol + Isoniazid + Pyrazinamide + Rifampicin. Finish the full course of the medication, even if you feel better. Stopping the course early increases the risk of coming back of the infection.

Hypersensitivity, history of drug-induced hepatitis, acute liver disease, peripheral or optic neuritis, renal dysfunction, epilepsy, chronic alcoholism.

Rifampicin: Induces microsomal enzymes (accelerates clearance of methadone, oral anticoagulants, glucocorticoids, oestrogen, oral hypoglycaemic agents, digitoxin, antiarrhythmics, theophylline, anticonvulsants, ?-blockers, azole antifungal, cyclosporin). INH: Inhibits metabolism of antiepileptics, benzodiazepines, warfarin, theophylline. Increases metabolism of enflurane. Alcohol, ASA, Al-containing antacids, corticosteroids, ketoconazole, propranolol. PZA: Decreases efficacy of gout therapy agents. Ethambutol: Neurotoxic agents.

[UNSAFE] Consuming alcohol while taking Ethambutol + Isoniazid + Pyrazinamide + Rifampicin may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

[CONSULT YOUR DOCTOR] Ethambutol + Isoniazid + Pyrazinamide + Rifampicin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Ethambutol + Isoniazid + Pyrazinamide + Rifampicin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Ethambutol + Isoniazid + Pyrazinamide + Rifampicin should be used with caution in patients with kidney disease. Dose adjustment of Ethambutol + Isoniazid + Pyrazinamide + Rifampicin may be needed. Please consult your doctor. Kidney function tests are advisable before the start of this medicine. [CAUTION] Ethambutol + Isoniazid + Pyrazinamide + Rifampicin should be used with caution in patients with liver disease. Dose adjustment of Ethambutol + Isoniazid + Pyrazinamide + Rifampicin may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised before and after the start of the treatment.

Born TB medicine for week patient whoes taking less food.blood 9gram.urin drain more then taking water .alsar in stomk.samisolid dait . Both legs not working Tab AKT-4 kit once daily For complete prescription detailed evaluation of the patient's condition is required I want to know about the food supplements I m taking AKT KIT from 4 months can i take weight gainer supplements? Healthy weight gain is important, so focus on diet and exercise both-eat dates milkshake, nut, paneer, eggs, non-veg, fruits and fruit milkshake and home-cooked meals do some weight training, with proper exercise you can also include some protein supplements for personalized diet chart write to me on Dear sir, I am kumar Gautam & my wife name is PATIENT suffering of infertility problem during 4 years. Tb pcr detected during laparoscopy & hysterocopy operation. suggest Akt 4 tablet for 2 months than Akt3 tablets for 4 months.just 3 months completed today. My wife is suffering dry caugh from 2 months. Is dry cough side effects from Akt 4 and Akt 3 tablets. Sir/Madam Give me the best solutions Regard Kumar Gautam Berhampore no usually att does not lead to cough but still she has stopped it so see for a few days whether it stops. Also i dont know about the cause of your infertility problem but you can go through my website www.drsonubalhara.in Sir I'm a tb patient and I have been said to take Akt-4 and few other medines for a period of time,but unfortunately I missed my two doses of AKT-4 so I want to ask that will I have to restart my doses from the beginning. If only two doses are missed continue as before no need to re start My Doctor has advised to have AKT 4 for one month. I am consuming those tabs from 15 days. Yesterday i have undergone the lever Function test. Please find the attached report and kindly advise whether we should continue using AKT 4 tabs or not? u can continue with liv 52 tab thrice a day after breakfast, after lunch, after dinner I have oncular tuberculosis (NOW CURED) in my eyes since may 2015 taken AKT KIT FOR 6 MONTHS at present my vision is 10% in right eye and 50% in left it could be due to scarringonce scar develop at your central retina almost impossible to cureif he cud help Can I take weight reduction course with akt 4 treatment? It include garcinia Cambogia plant extract capsule, apple cider vinegar and slim shake. no u should not take anything , first complete ur AKT full course Six years back detected TB in my uterus and Doctor prescribed me AKT 4 & AKT 3 for 6 months. I completed it in 7 months because in between I was not taking this medicine in regular basis as doctor prescribed me to take regularly without fail. In this 6 years I couldn't conceive. My question is can I take AKT 4 & AKT 3 for six months once again without any laproscopy test? As I know there is so many side effects of these medicine but is there any such side effect which will really harmful for my health in future or anyway. I don't want to go to doctor's clinic again and again. I just want to save my time and money. Please advise me needful. Thanks PATIENT Well no need for medicine againIf u want a child get IVFICSI done as ur age is not on your side