Fludrocortisone Acetate

Fludrocortisone Acetate belongs to a group of medicines called steroids. It is used in the treatment of Addison's disease (inadequate production of natural steroid hormones by the adrenal glands) and congenital adrenal hyperplasia (a genetic condition that affects the adrenal glands). Fludrocortisone Acetate should be taken with food. This will prevent you from getting a stomach upset. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tell you so. Use of this medicine may cause few common side effects such as behavioral changes, weight gain, bone disorder, and skin thinning. Let your doctor know if any of these side effects bother you. If this medicine is used for a long time, you may have to get regular tests to check your bone density. Before taking this medicine, inform your doctor if you have any problems with your kidneys or liver. This medicine can also make it harder for you to fight off infections. Tell your doctor if you have any signs of infection such as fever or sore throat. If you are pregnant or breastfeeding, you should let your doctor know before using the medicine. Fludrocortisone Acetate is a steroid medicine. It works by decreasing the amount of sodium that is removed through urine.

• Addison's disease • Congenital adrenal hyperplasia

Potent mineralocorticoid with high glucocorticoid activity; Fludrocortisone promotes increased reabsorption of sodium and excretion of potassium from renal distal tubules

Adult Dose: Oral Adult: Primary adrenocortical insufficiency Adrenocortical Insufficiency/Addison Disease Primary and secondary adrenocortical insufficiency in Addison disease Usual, 0.1 mg/day PO; range, 0.1 mg PO 3 times weekly to 0.2 mg/day PO If hypertension occurs: 0.05 mg/day PO Salt-Losing Forms of Congenital Adrenogenital Syndrome 0.1-0.2 mg/day PO Child Dose: Not FDA-approved for use in children

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Fludrocortisone Acetate is to be taken with food.

If you miss a dose of Fludrocortisone Acetate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Behavioural changes • Weight gain • Bone disorder • Thinning of skin • Altered blood sugar level • Mood changes • Upset stomach

[SAFE] Fludrocortisone Acetate does not usually affect your ability to drive. Fludrocortisone Acetate is used for the treatment of addison’s disease (Inadequate production of natural steroid hormones by the adrenal glands). It is also effective in correcting electrolyte imbalances associated with Addison's disease. Take it with food to avoid stomach upset. Your doctor may get regular blood tests done to monitor the levels of electrolytes (such as sodium) in your blood while you are taking this medicine. Regularly monitor your blood pressure, your salt intake in foods, and your weight. Inform your doctor if you notice any changes. Let your doctor know you're on this medicine before you receive any vaccines. It can re-activate any old infections you may have. Inform your doctor if you have or had hepatitis B, C, or tuberculosis. Do not stop taking the medication suddenly without talking to your doctor first.

Hypersensitivity. Hyperalbuminaemia; hypertension, systemic fungal infections.

May decrease salicylate levels. Anticholinesterase effects are antagonised. Decreased effects with rifampin, barbiturates, hydantoins and phenytoin. Oral contraceptives or ritonavir may increase the plasma concentrations of fludrocortisone. Increased potassium loss with potassium-depleting drugs e.g. thiazides, furosemide or amphotericin B. Increased risk of GI bleeding or ulceration with NSAIDs. May alter efficacy of anticoagulants when used concurrently.

[UNSAFE] It is unsafe to consume alcohol with Fludrocortisone Acetate.

[CONSULT YOUR DOCTOR] Fludrocortisone Acetate may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Fludrocortisone Acetate during breastfeeding is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Fludrocortisone Acetate in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Fludrocortisone Acetate in patients with liver disease. Please consult your doctor.

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