Fluorometholone 0.1% + Gentamicin 0.3% Eye prep

Fluorometholone 0.1% + Gentamicin 0.3% Eye prep is used for allergic and inflammatory conditions of the eye. It stops bacterial growth and reduces inflammation.

Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation. Gentamicin is an aminoglycoside that binds to 30S and 50S ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

• Allergic and Inflammatory Eye Conditions: Used for acute and chronic conjunctivitis, keratitis, iridocyclitis, iritis, scleritis, episcleritis.
• Post-operative Infections: Used for prevention of infections after strabotomy, cataract and glaucoma surgery.

Ophthalmic steroid - antibiotic combined preparations

Corticosteroid + Aminoglycoside Antibiotic

Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation. Gentamicin is an aminoglycoside that binds to 30S and 50S ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Fluorometholone reduces inflammation; Gentamicin inhibits bacterial protein synthesis to stop bacterial growth.

Adult Dose (Ophthalmic):

• Bacterial infection (Suspension): 1 drop 5 times daily into conjunctival sac; severe cases: 1 drop per hour for 1-2 days.
• Post-operative infection (Suspension): 1 drop 4 times daily for 1 week; then reduced frequency.
• Bacterial infection (Ointment): Apply 3-4 times daily into the affected eye.
• Post-operative infection (Ointment): Apply before retiring to support suspension therapy.

For external use only. Shake well before use. Hold the dropper close to the eye without touching it. Place the medicine inside the lower eyelid. Wipe off extra liquid.

If you miss a dose of Fluorometholone 0.1% + Gentamicin 0.3% Eye prep, apply it as soon as possible; however, if it is almost time for your next dose, skip the missed dose.

Side Effects:

• Transient burning sensation after instillation
• Rare: Hypersensitivity reactions (eczema of eyelid, puncture keratitis)
• Prolonged use: Delayed wound healing, increased IOP, cataract formation, thinning of cornea and sclera

Precautions:

• Steroids can mask, activate or aggravate ocular infections.
• Long term treatment with steroid may enhance thinning of cornea and sclera; rarely perforation reported.
• If no improvement after 7-8 days, other therapeutic means should be considered.
• Patients experiencing blurred vision after application should refrain from driving or operating machinery.
• Contact lenses should be removed before each application.

Contraindications:

• Hypersensitivity
• Injuries and ulceration of the cornea
• Viral infections (Herpes simplex, Vaccinia)
• Mycosis
• Eye tuberculosis
• Glaucoma

Drug Interactions: When using with other topical eye medications, leave several minutes between applications.

Food Interactions: No interaction found/established.

Use in Pregnancy: May be unsafe; consult your doctor.

Use in Lactation: No adequate information; caution required.

Pediatric Use: Safety and efficacy not established.

Geriatric Use: No specific dosage adjustment is necessary for elderly patients.

Renal Impairment: No specific precautions necessary (minimal systemic absorption due to topical use).

Hepatic Impairment: No specific precautions necessary (minimal systemic absorption due to topical use).

Overdose: Limited information on topical overdose; excessive use may cause eye irritation.

Storage: Store in a cool and dry place, protected from light. Keep out of reach of children.

Fluorometholone 0.1% + Gentamicin 0.3% Eye prep