Gentamicin 0.1% Topical

Introduction: Gentamicin 0.1% Topical is an antibiotic used to treat minor skin infections (eg. folliculitis). It may also be used to treat infected cuts and wounds. This medicine stops the bacteria from growing, which helps to resolve your symptoms and cure the underlying infection.

How it works: Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective and stopping bacterial growth.

Important Information: For external use only. Apply to the affected area 3-4 times daily. Before application, wash the area with soap and water and dry thoroughly. If crusts are present, remove them before application to provide maximum contact with the infecting organisms.

• Burn
• Eczema
• Seborrheic dermatitis
• Ecthyma
• Excoriation
• Folliculitis
• Furunculosis
• Insect bites and stings
• Lacerations and abrasions
• Paronychia
• Pyoderma gangrenosum
• Skin cysts and abscesses
• Stasis ulcers and infected skin ulcers
• Bacterial, fungal or viral superinfection
• Sycosis barbae
• Minor surgical wounds
• Infected contact dermatitis

Aminoglycosides, Topical Antibiotic preparations

Aminoglycoside antibiotic

Gentamicin Sulphate is an aminoglycoside antibiotic. It is a proven bactericidal antibiotic active against Gram-positive & Gram-negative pathogens including E. coli, Klebsiella, Proteus, Pseudomonas aeruginosa and penicillin resistant strains of Staph. aureus. In common with other aminoglycoside antibiotics, it appears to interfere with protein synthesis of the bacterial cell.

Gentamicin inhibits bacterial protein synthesis on the ribosome, thereby stopping bacterial growth and reproduction.

Adult Dose:

• Apply to the affected area 3-4 times daily
• Wash the area with soap and water and dry thoroughly before application
• If crusts present, remove before application

Child Dose (1+ year):

• Apply to the affected area 3-4 times daily

* Use as directed by the registered physician

For external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment. Wash your hands after applying, unless hands are the affected area.

If you miss a dose, consult your doctor.

Common Side Effects:

• Application site irritation
• Itching
• Redness
• Swelling

Precautions:

• If the area becomes more irritated or infected, stop using and consult your doctor.
• Avoid contact with eyes, nose or mouth (rinse with water).
• Prolonged use may cause overgrowth of non-susceptible organisms.

Contraindications:

• History of hypersensitivity to aminoglycosides
• Pregnancy
• Hepatic impairment
• Skin rash

Drug Interactions:

• Synergistic with ampicillin, benzylpenicillin and other beta-lactam antibiotics
• Increased risk of severe respiratory depression with anaesthetics or opioids
• Increased incidence of ototoxicity with ethacrynic acid and furosemide

Food Interactions: No interaction found/established.

Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects.

Use in Lactation: Probably safe during breastfeeding. Limited data suggests the drug does not represent significant risk to the baby.

Pediatric Use: Dosage available for children 1 year and older.

Geriatric Use: Use as per doctor's advice for elderly patients.

Renal & Hepatic Impairment: No interaction found/established (minimal systemic absorption due to topical use).

Overdose: Overdose is unlikely when used as directed. Excessive use may cause skin irritation.

Storage: Store below 30°C and protected from light. Keep out of reach of children.

Gentamicin 0.1% Topical Ointment