Gentamicin 0.3% Topical

Introduction: Gentamicin 0.3% Topical is an antibiotic used for bacterial skin infections, burns, eczema, folliculitis, furunculosis, insect bites, lacerations and abrasions.

How it works: Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Important Information: For external use only. Apply to the affected area 3-4 times daily. Clean the area before application.

• Bacterial skin infections
• Burns
• Eczema
• Seborrheic dermatitis
• Ecthyma
• Excoriation
• Folliculitis
• Furunculosis
• Insect bites and stings
• Lacerations and abrasions
• Paronychia
• Pyoderma gangrenosum
• Skin cysts and abscesses
• Stasis ulcers and infected skin ulcers
• Bacterial, fungal or viral superinfection
• Sycosis barbae
• Minor surgical wounds
• Infected contact dermatitis

Topical Antibiotic

Aminoglycoside antibiotic

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Gentamicin inhibits bacterial protein synthesis on the ribosome, thereby stopping bacterial growth and reproduction.

Adult Dose:

• Apply to the affected area 3-4 times daily

Child Dose (1+ year):

• Apply to the affected area 3-4 times daily

* Use as directed by the registered physician

For external use only. Use it in the dose and duration as advised by your doctor. Clean and dry the affected area and gently massage the ointment.

If you miss a dose, consult your doctor.

Common Side Effects:

• Allergic contact dermatitis
• Erythema
• Pruritus

Precautions:

• Caution with concurrent use of neuromuscular blocking agents.
• Caution in myasthenia gravis, parkinsonism.
• Caution in conditions predisposing to ototoxicity and nephrotoxicity.
• Monitor plasma concentrations in high doses or prolonged courses.
• Monitor auditory and renal functions.

Contraindications:

• History of hypersensitivity to aminoglycoside
• Pregnancy
• Hepatic impairment
• Skin rash

Drug Interactions:

• Synergistic with ampicillin, benzylpenicillin and other beta-lactam antibiotics
• Increased risk of severe respiratory depression with anaesthetics or opioids
• Increased incidence of ototoxicity with ethacrynic acid and furosemide

Food Interactions: No interaction found/established.

Use in Pregnancy: Unsafe during pregnancy. Animal studies have shown harmful effects.

Use in Lactation: Safe during breastfeeding. Gentamicin is excreted in breast milk but no adverse effect on nursing infant.

Pediatric Use: Dosage available for children 1 year and older.

Geriatric Use: Use as per doctor's advice for elderly patients.

Renal & Hepatic Impairment: Contraindicated in hepatic impairment. Caution in kidney disease.

Overdose: Overdose is unlikely when used as directed. Excessive use may cause skin irritation.

Storage: Store below 30°C, away from light. Keep out of reach of children.

Gentamicin 0.3% Topical Ointment