Gentamicin 0.3% + Hydrocortisone Acetate 1% Eye prep

Introduction: Gentamicin 0.3% + Hydrocortisone Acetate 1% Eye prep is a combination medicine used for bacterial eye infections and inflammation. It stops bacterial growth and helps in relieving redness, itching and swelling.

How it works: Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis. Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects.

Important Information: For ophthalmic use only. Wash hands before use. Do not wear contact lenses during treatment. Use within 4 weeks of opening.

• Susceptible infections
• Keratitis
• Allergic conjunctivitis
• Blepharitis
• Allergic and inflammatory conditions of the eye
• Chronic conjunctivitis
• Spring catarrh

Hydrocortisone & Combined preparations, Ophthalmic steroid - antibiotic combined preparations

Aminoglycoside + Corticosteroid

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective. Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.

Gentamicin inhibits bacterial protein synthesis to control infection and Hydrocortisone reduces inflammation, redness and itching.

Adult Dose (Ophthalmic):

• Eye drops: Instill 1-2 drops 4 hourly, up to 2 drops hourly in severe cases
• Eye ointment: Apply 1/2 inch into the conjunctival sac 2-3 times daily

* Use as directed by the registered physician

For ophthalmic use only. Use in the dose and duration as advised by your doctor. Wash hands before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid.

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular schedule.

Common Side Effects:

• Allergic contact dermatitis
• Transient irritation
• Burning
• Stinging
• Increased redness
• Lacrimation

Precautions:

• Caution with concurrent use of neuromuscular blocking agents.
• Caution in myasthenia gravis, parkinsonism.
• Caution in conditions predisposing to ototoxicity and nephrotoxicity.
• Monitor plasma concentrations in high doses or prolonged courses.

Contraindications:

• History of hypersensitivity to aminoglycoside
• Pregnancy
• Hepatic impairment

Drug Interactions:

• Gentamicin: Additive effect with other neurotoxic and nephrotoxic drugs
• Hydrocortisone: Thiazides may enhance hyperglycaemia and hypokalaemia

Food Interactions: No interaction found/established.

Use in Pregnancy: Unsafe during pregnancy. Animal studies have shown harmful effects.

Use in Lactation: Use with caution during breastfeeding. Assess potential risks and benefits.

Pediatric Use: Use as per doctor's advice for children.

Geriatric Use: Use as per doctor's advice for elderly patients.

Renal & Hepatic Impairment: Contraindicated in hepatic impairment. Caution in kidney disease.

Overdose: Overdose is unlikely when used as directed. Excessive use may cause eye irritation.

Storage: Store in a cool and dry place. Protect from light and freezing. Discard contents one month after opening.

Gentamicin 0.3% + Hydrocortisone Acetate 1% Eye prep