Granisetron

Granisetron is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy. Granisetron will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember, you should not stop taking this medicine suddenly without talking to your doctor. In case you vomit within one hour of taking a dose, then take another dose and avoid heavy meals throughout the day. The most common side effects of taking this medicine include headache, constipation, diarrhea and weakness. Dizziness and sleepiness may also occur, so do not drive or do anything that requires mental focus until you know how this medicine affects you. These symptoms should disappear when you stop taking the medicine but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them. Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicine that you might be using, especially medicines to treat epilepsy, heart problems, cancer and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your healthcare team. Granisetron is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

• Nausea • Vomiting

Granisetron is a selective 5-HT3-receptor antagonist with little or no affinity for other serotonin receptors. It blocks serotonin in the chemoreceptor zone.

Adult Dose: Chemotherapy Induced Nausea & Vomiting Oral 1 mg PO 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemotherapy IV 0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy Radiation-Induced Nausea & Vomiting 2 mg PO, 1 hr before radiation treatment Postoperative Nausea & Vomiting Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia Treatment: 1 mg (undiluted) IV push over 30 seconds Elderly: Chemotherapy Induced Nausea & Vomiting Oral: 2 mg 1 hr before chemotherapy, then 1 mg 12 hr after 1st dose; OR 2 mg 1 hr before chemo IV: 0.01 mg/kg/dose infused over 5 min or direct injected over 30 sec, 30 min before chemotherapy Radiation-Induced Nausea & Vomiting 2 mg PO, 1 hr before radiation treatment Postoperative Nausea & Vomiting Prevention: 1 mg (undiluted) IV push over 30 seconds; administer before anesthetic induction or immediately before reversal of anesthesia Treatment: 1 mg (undiluted) IV push over 30 seconds Hepatic impairment No dosage adjustment required Child Dose: Chemotherapy Induced Nausea & Vomiting <2 years: Safey and efficacy not established 2-16 years: As adults; 0.01 mg/kg infused over 5 min or direct inj over 30 sec, 30 min before chemotherapy Oral administration: Currently FDA-approved for IV administration in children; safety and efficacy of oral administration is not established Postoperative Nausea & Vomiting Safety and efficacy not established Not approved for postoperative N/V in pediatric patients because of lack of efficacy and QT prolongation observed in clinical trials Renal Dose: Renal impairment IV Severe (CrCl <30 mL/min): Total clearance was not affected in patients with severe renal failure who received a single 40 mcg/kg IV dose PO No dosage adjustment required

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Granisetron may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Granisetron, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Sleepiness • Weakness • Headache • Constipation • Diarrhea

[SAFE] Granisetron does not usually affect your ability to drive. You have been prescribed Granisetron for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy. Unlike some other nausea medicines, the side effects for Granisetron are relatively mild. It is fast-acting and starts working within 30 minutes. If you vomit within one hour of taking a dose, take another dose. Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.

Hypersensitivity.

Phenobarbital may induce metabolism of granisetron.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Granisetron. Please consult your doctor.

[SAFE IF PRESCRIBED] Granisetron is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Granisetron is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Granisetron is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Granisetron may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Granisetron is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Granisetron may not be needed in these patients. Please consult your doctor.

My wife is 13 week pregnent her docter change her tablet from mvista to doxynate plus me I know the reason is both tablet aee same. Docter asked to taje doxynate plus 2 tablet at bed time.please suggest. Doxynate is tablet to stop vomiting dear. It is ok to take them at bed time. It is widely recommended to take for nausea and vomiting of pregnancy. Gastric nausea vomiting reflux sompraz D 40 mg twice daily 1 hour before meal for 10 days NAUSEA AND VOMITING DUE TO COLD Tab Domstal 1 tab Stat and keep yourself warm I am 72 days pregnant. I can&#x27;t able to eat anything. Always feeling vomiting. I am more worried about my baby. Will my baby get sufficient nutrition? Please start taking Doxinate tablet thrice a day to prevent nausea. As nausea decreases, you should be able to eat properly. 1 trimister me iron supplement liya to chale ga kya? Iron supplements are not advised in 1st trimester as it increases nausea and vomiting and even causes contipation, all problems already troublesome in the first trimester. What is side effect of primolut n Bloating, pain abdomen, nausea, vomiting etc are common side of Primolut. I am in the first month of pregnancy and I am experiencing nausea, vomiting, stomach pain (moderate to severe) as well as discomfort. Current medications is Susten SR 200 (OD), Duvadilan retard (OD), Doxinate (BD), Folverine D (OD), Fertigyn 500 (1 amp weekly) and aciloc 150 (BD). What should I do to ease my situation. Please suggest The med suggested are to support of pregnancy and for acidity and nausea and vomiting. Continue the same. You can upgrade the med for vomiting after consulting your Fever since 7 days and also nausea and vomiting Tab Pacimol 1 tab SOS and Tab Domstal 1 tab STAT and1 tab SOS. Sine the fever has 7 days of history you must visit your Doctor