Heparin Sodium

Heparin Sodium is an anticoagulant which prevents abnormal clotting of blood. It not only prevents the formation of harmful blood clots in the legs, lungs, and heart but also stops them from growing bigger. Heparin Sodium is administered under the supervision of a doctor. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the most benefit, even if you feel fine. It is preventing future harm. Your doctor may get regular blood tests done to make sure this medicine is working well and monitor the levels of potassium and platelets. Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool. You should be careful while shaving, cutting nails, using sharp objects, or engaging in contact sports. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Heparin Sodium is an anticoagulant. It works by preventing the formation of harmful blood clots. Although it does not dissolve the existing blood clots, it prevents them from growing larger and causing blockages in the blood vessels.

• Blood clots

Heparin increases the inhibitory action of antithrombin III (AT III) on clotting factors XIIa, XIa, IXa, Xa and thrombin. This inhibits the conversion of prothrombin to thrombin and fibrinogen to fibrin. It also inhibits platelet function. It may reduce the activity of ATIII at very high doses.

Adult Dose: DVT & Pulmonary Embolism Prophylaxis 5000 units Subcutaneous(SC) q8-12hr, OR 7500 units SC q12hr Treatment 80 units/kg IV bolus, THEN continuous infusion of 18 units/kg/hr, OR 5000 units IV bolus, THEN continuous infusion of 1300 units/hr, OR 250 units/kg (alternatively, 17,500 units) SC, THEN 250 units/kg q12hr Acute Coronary Syndromes PCI Without GPIIb/IIIa inhibitor: Initial IV bolus of 70-100 units/kg (target ACT 250-300 sec) With GPIIb/IIIa inhibitor: Initial IV bolus of 50-70 units/kg (target ACT >200 sec) STEMI Patient on fibrinolytics: IV bolus of 60 units/kg (max: 4000 units), THEN 12 units/kg/hr (max 1000 units/hr) as continuous IV infusion Dose should be adjusted to maintain aPTT of 50-70 sec Unstable Angina/NSTEMI Initial IV bolus of 60-70 units/kg (max: 5000 units), THEN initial IV infusion of 12-15 units/kg/hr (max: 1000 units/hr) Dose should be adjusted to maintain aPTT of 50-70 sec Anticoagulation Intermittent IV injection 8000-10,000 units IV initially, THEN 50-70 units/kg (5000-10,000 units) q4-6hr Continuous IV infusion 5000 units IV injection, followed by continuous IV infusion of 20,000-40,000 units/24 hr Catheter Patency Prevention of clot formation within venous and arterial catheters Use 100 units/mL; instill enough volume to fill lumen of catheter Child Dose: Venous Thromboembolic Prophylaxis 100-150 units/kg IV once Venous Thromboembolic Treatment 1 year Loading dose of 75 units/kg IV, THEN 20 units/kg/hr IV as initial maintenance dose I ntermittent IV injection Initially give 50-100 units/kg IV infusion, THEN 100 units/kg IV infusion q4hr as a maintenance dose

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Heparin Sodium, please consult your doctor.

>10% Heparin-induced thrombocytopenia, possibly delayed (10-30% ) Frequency Not Defined Mild pain,Hematoma,Hemorrhage,Local irritation,Erythema,Injection site ulcer (after deep SC injection),Increased liver aminotransferase,Anaphylaxis,Immune hypersensitivity reaction,Osteoporosis (long-term, high-dose use) Potentially Fatal: Heparin-induced thrombocytopenia with or without thrombosis; bleeding.

[SAFE] Heparin Sodium does not usually affect your ability to drive. Notify your doctor if you see blood in your urine or stool or any unusual bleeding from your skin, gums or nose. Inform your doctor if you experience rash, itching, swelling of the face, tongue, and throat while you receive this medicine.

Patients predisposed to active bleeding including thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, haemorrhagic blood disorders, bacterial endocarditis, severe hypertension, oesophageal varices. Recent surgery at sites where haemorrhage would be an especial risk. Severe renal and hepatic impairment. Cerebral or subarachnoid haemorrhage, abdominal or thoracic bleeding into closed space, severe traumatic bleed, hepatic, renal, splenic or arterial injury, severe haemostatic defect, arterial thrombosis with heparin-associated thrombocytopenia. IM admin.

Enhanced anticoagulant effect w/ other drugs affecting platelet function or the coagulation system (e.g. platelet aggregation inhibitors, thrombolytic agents, salicylates, NSAIDs, vit K antagonists, dextrans, activated protein C). Decreased anticoagulant effect w/ gyceryl trinitrate infusion. Increased risk of hyperkalaemia w/ ACE inhibitors or angiotensin II antagonists.

[UNSAFE] It is unsafe to consume alcohol with Heparin Sodium.

[CONSULT YOUR DOCTOR] Heparin Sodium may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Heparin Sodium is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Heparin Sodium is released in small amounts in the breast milk and amounts reaching the baby are also small, which would not be expected to cause any harmful effects to the baby.

[SAFE IF PRESCRIBED] Heparin Sodium is safe to use in patients with kidney disease. No dose adjustment of Heparin Sodium is recommended. However, inform your doctor if you have any underlying kidney disease. [CONSULT YOUR DOCTOR] There is limited information available on the use of Heparin Sodium in patients with liver disease. Please consult your doctor.

I am not getting pregnant while dnc has done Because there was miscarriage 4 month back Low molecular weight heparin Why low molecular weight heparin used in pregnancy It's used only in high risk pregnancy and in certain condition like APLA to prevent miscarriage PATIENT a heart attack before 2days luckily we saved him by taken him to the nearest hospital where a cardiologist has given complete first aid treatment he was under observation in icu for 2 days now shifted to general ward now the complication is he has hypertension and his platet counts is lower to 85000. Now my question is will the bypass surgery or angioplasty will help him to be normal as the platet count is low the cardiologist advises us not to undergo any operation Pls advice Thank you Khaja Your advice and help will be highly appreciated Angioplasty is better however need to see cause of low pkateletsWas he on heparin 26 w pregnant. Emergency sutures at 19w due to incompetent cervix. At 25 w scan baby growth 1w lagging n marginally restrictd fliw to the umbilical artery. suggested heparin injection daily. Will it cause any problem to my baby? Heaparin injections is advised in pregnancy in such cases. Do not worry, it is safe. My father in law is being admitted in hospital due to blood clot in brain. His right leg and arm seems to be paralysed. Doctors in the hospital not briefing us on the problem exactly. Need your second opinion. His age is 67. Having Smoking habit. There are blood clots in the brain arteries She just checked that she is pregnant and doctor prescribed her LUPI-HCG 5000IU INJECTION .because last tym miscarriage. This injection is safe? Yes PATIENT injection is absolutely safe. Go ahead with it (1)-My wife (eag-32) had the cortical venious thrombosis during pregnancy. She was cantinue taken (7mounth) LMWH injection (60-mg per day 2). Afterall 7 month pregnancy loss (2)after- she was taken warfarin for next 6 month. And after 1 month no medician for thrombopholia diagnosis test name and results Test no (1)torch- nigetive, (2)keriyotype- nigative(3) ANA Blot 17 antigens, serum - Nigative.(4) Factor V Leiden, Mutant detection. - Nigative.(5)Protein S Activity. - Nigative.(6)Protein C Activity & Antigen. - Nigetive.(7)Anti Thrombin lll Activity. - Nigative.(8)S. Homocysteine. - Nigative.(9)APA (Phospolipid)-IGM.- Nigative.(10)Beta-2-Glycoprotein 1- IgG/IGM. - Nigative.(11)Cardiolipin AntibodyACL- IgG/IGM. - Nigative.(12)Lupus anticoagulants (LAC) Profile. - Nigative.(1Thyroid Stimulating Hormone. - Nigative. So all test refrance renge is normal and hematologist doctors check the report and say this lady is normal but maybe Next time it could be too risk # so what we do for next pregnancy? And which tritment and therapeutic dosage. (Short note in whole thing - my wife previous 7 mounth pregnancy loss because during pregnancy blood clot (cortical venious thrombosis) may be in placenta and doctors say she is need a heparin (lmwh) injection in next pregnancy first day to nine month last day delly per day 2 but injection cost is very high and main thing is per day 2 injection is very painfull so plz suggest tritment and good doctor) I am stay in Bombay) as she had thrombosis in this pregnancy there is chance of recurrence so in next pregnancy she will need heparin or enoxaprin injections along with ecosprin if required, definitale the cost is high but in bulk from supplier you will get at cheaper rate. Sodium level of blood drops frequently Ok send me your all reports