Imiquimod

Imiquimod is used in the treatment of genital warts, rough and scaly patches that appear due to exposure to the sun and a certain type of skin cancer. It works by triggering the immune system to fight against the virus responsible for these warts. Imiquimod is for external use only. You should always use it exactly as your doctor has told you. The affected area should be clean and dry before application. You must wash your hands thoroughly before and after applying this medicine. This medicine should be used regularly to get the most benefit from it. Do not use more than you need as it will not clear your condition faster and some side effects may be increased. If your condition goes on for longer than four weeks or gets worse at any time, let your doctor know. You can help this medicine work better by keeping the affected areas clean, making sure they are dry and washing your hands before and after treating the infection. Common side effects include application site reactions like itching, burning, redness, dryness, swelling, and skin ulceration. Please consult your doctor if these side effects persist for a longer duration. Avoid direct contact of the Imiquimod with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. Imiquimod works in genital warts by triggering the immune system to produce natural substances which help fight against the virus, that causes warts. Researchers don't know how exactly it works in actinic keratosis or basal cell cancer.

• Genital warts (Skin bumps on or around the genital or anal area) • Actinic keratosis • Basal cell cancer

Imiquimod, an immune response modifier, is a Toll-like receptor 7 agonist that activates immune cells. The exact mechanism of action is not yet elucidated. It has no direct viral activity, however, it is effective against viral infection and acts as antitumour agent by induction of interferon-α (IFN-α) and other cytokines.

Adult Dose: Topical/Cutaneous Anogenital warts Adult: As 3.75% cream: Apply thinly onto affected area once daily until total clearance or for a Max duration of 8 weeks. As 5% cream: Apply 3 times weekly (non-consecutive days) for up to 16 weeks. Perianal warts Adult: As 3.75% cream: Apply thinly onto affected area once daily until total clearance or for a Max duration of 8 weeks. As 5% cream: Apply 3 times weekly (non-consecutive days) for up to 16 weeks. Superficial basal cell carcinoma Adult: As 5% cream: Apply 5 times weekly (on consecutive days) before bedtime for 6 weeks, assess response 12 weeks after completing treatment. Actinic keratoses Adult: As 2.5% or 3.75% cream: Apply unto face or scalp once daily before bedtime for 2 weeks, repeat course after a 2 weeks treatment-free interval, assess response 8 weeks after 2nd course. As 5% cream: Apply 3 times weekly before bedtime for 4 weeks, repeat for further 4 weeks with a 4-week interval, if necessary; or alternatively, apply 2 times weekly for 16 weeks. Child Dose: <12 years: Safety and efficacy not established

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

If you miss a dose of Imiquimod, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Dry skin

No interaction found/established

Hypersensitivity

No interaction found/established

[CONSULT YOUR DOCTOR] Imiquimod may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Imiquimod is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

No interaction found/established No interaction found/established

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