Generic
Isopropamide + Trifluoperazine
3 brands available in the market
At a glance
Isopropamide + Trifluoperazine combination is used for the treatment of Irritable Bowel Syndrome (IBS), relieving abdominal pain, cramping, bloating, and diarrhea or constipation.
Description
Isopropamide + Trifluoperazine is a combination medicine used for the treatment of Irritable Bowel Syndrome. Isopropamide is an anticholinergic which works by blocking the binding of acetylcholine to its receptor in nerve cells, relaxing smooth muscles in the digestive tract and decreasing spasms. Trifluoperazine is a typical antipsychotic that works by blocking the action of dopamine in the brain. This combination relieves abdominal pain and cramps and helps with easy passage of gas.
Indications
- Irritable Bowel Syndrome (IBS)
Therapeutic class
Antipsychotic & related drugs
Pharmacological class
Anticholinergic + Typical Antipsychotic
Pharmacology
Isopropamide is an anticholinergic which works by blocking the binding of acetylcholine to its receptor in nerve cells, relaxing smooth muscles in the digestive tract and decreasing spasms. Trifluoperazine is a typical antipsychotic that works by blocking the action of dopamine in the brain. This combination relieves abdominal pain and cramps.
Mechanism of action
Isopropamide blocks acetylcholine receptors to relax smooth muscle; Trifluoperazine blocks dopamine to work on brain.
Dosage
Adult Dose (Oral):
- Take in the dose and duration as advised by your doctor
- May be taken with or without food
Child Dose: No specific data; use as directed by physician
Administration
Take this medicine in the dose and duration as advised by your doctor; swallow the whole tablet; do not chew, crush or break; may be taken with or without food; better to take at a fixed time.
Missed dose
If you miss a dose, take it as soon as possible; if it is almost time for your next dose, skip the missed dose and go back to regular schedule; do not double the dose.
Side effects
Common Side Effects:
- Nausea
- Constipation
- Dryness in mouth
- Weight gain
- Sleepiness
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Dizziness
- Blurred vision
- Difficulty in urination
Precautions & warnings
Precautions:
- Isopropamide + Trifluoperazine may affect your ability to drive (dizziness, drowsiness, blurred vision)
- Avoid alcohol (may increase drowsiness)
- Lifestyle modifications (fiber-rich diet, avoiding trigger foods, increasing fluid intake, regular exercise) can help
- Inform doctor if you have kidney or liver disease
- Inform doctor if pregnant, planning pregnancy or breastfeeding
Contraindications
Contraindications:
- Hypersensitivity to any ingredients
- Liver disease (not considered safe as per available data)
Drug interactions
Drug Interactions:
- Other medications may affect or be affected by this medicine
Food interactions
Food Interactions: Isopropamide + Trifluoperazine may cause excessive drowsiness with alcohol.
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Use in lactation
Use in Lactation: Probably unsafe; limited data suggests drug may pass into breastmilk and harm baby.
Pediatric use
Safety and efficacy in pediatric patients have not been established.
Geriatric use
No specific data for elderly; however caution advised.
Renal / hepatic impairment
Renal Impairment: Limited information available; consult your doctor.
Hepatic Impairment: Limited information available; not considered safe in liver disease as per available data; consult your doctor.
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.
Chemical structure
Isopropamide + Trifluoperazine