Generic
Loratadine
46 brands available in the market
At a glance
Loratadine is an antihistamine used for the treatment of allergic conditions. It relieves allergy symptoms such as itching, swelling, and rashes.
Description
Loratadine is a non-sedative histamine H1 receptor antagonist with antiallergic properties. It is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonistic activity and no central sedative or anticholinergic effect. It is rapidly effective and long-lasting, allowing once-a-day administration.
Indications
- Seasonal allergic rhinitis
- Perennial allergic rhinitis
- Chronic idiopathic urticaria
- Skin allergies (itching, swelling, rash)
Therapeutic class
Non-sedating Antihistamines
Pharmacological class
H1 Receptor Antagonist
Pharmacology
Loratadine competitively binds to H1 receptors, blocking the effects of histamine, an allergic mediator.
Mechanism of action
Reduces allergic reactions by blocking H1 receptors.
Dosage
Adult and 12 years+: 10 mg once daily
Children 2-12 years (>30 kg): 10 mg once daily
Children 2-12 years (<30 kg): 5 mg (½ tablet) once daily
Children <2 years: Safety not established; not recommended
Administration
- Swallow tablet whole; do not chew, crush or break
- Take on an empty stomach (in the morning or when symptoms require treatment)
- Take at the same time each day
Missed dose
If you miss a dose, take it as soon as possible. However, if it's almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common Side Effects:
- Sleepiness (less than other antihistamines)
- Increased appetite
- Headache (rare)
Precautions & warnings
- Caution when driving or doing activities requiring concentration (may cause mild dizziness)
- Avoid alcohol (may cause excessive drowsiness)
- Inform doctor if you have liver or kidney problems
Contraindications
- Hypersensitivity to Loratadine or its components
Drug interactions
- No potentiating effects with alcohol on psychomotor performance
- Cimetidine, erythromycin, ketoconazole may increase loratadine serum concentrations (no adverse effects reported)
Food interactions
Loratadine may cause excessive drowsiness with alcohol.
Use in pregnancy
Use in Pregnancy: Loratadine is generally considered safe during pregnancy (Category B). Animal studies have shown low or no adverse effects to the developing baby.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Loratadine is safe during breastfeeding; does not pass into breastmilk in significant amounts and does not cause sleepiness in infants.
Pediatric use
Safety not established in children under 2 years; dose established for children 2-12 years (weight-based).
Geriatric use
No dose adjustment may be needed in elderly; however, renal function should be considered.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed (eGFR <30 mL/min).
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed.
Overdose effects
Overdose (>10 mg): drowsiness, tachycardia, headache in adults; extrapyramidal signs and palpitations in children. Activated charcoal, gastric lavage, symptomatic treatment.
Storage conditions
Store in a dry place, away from light and heat; keep out of reach of children.
Chemical structure
Loratadine