Generic
Lyophilized bacterial lysates of E. coli
1 brands available in the market
At a glance
Lyophilized bacterial lysates of E. coli is an orally administered immunostimulant used for the prevention of recurrent lower urinary tract infections (UTIs) and as co-medication in acute UTIs.
Description
Uro-Vaxom (Lyophilized Bacterial Lysate of Escherichia coli) is an orally administered immunostimulant that enhances both innate and adaptive immune responses, bolstering the body's defense against urinary pathogens. It activates innate immune cells in Peyer's patches by stimulating pattern recognition receptors, initiating immune cell maturation which then migrate to the urinary tract, providing localized protection.
Indications
- Prevention of recurrent lower urinary tract infections (UTIs)
- Co-medication in acute urinary tract infections
Therapeutic class
Immunosuppressant
Pharmacological class
Bacterial Immunostimulant
Pharmacology
Uro-Vaxom stimulates PRRs in Peyer's patches to activate innate and adaptive immune cells, increasing cytokine production, enhancing phagocytosis, and producing IgA and IgG for humoral protection in the urinary tract.
Mechanism of action
Strengthens the body's immune defenses against urinary tract infections and reduces recurrence.
Dosage
Preventive treatment: 1 capsule daily, preferably in the morning on an empty stomach, for 3 consecutive months (90 days)
Acute episode treatment: 1 capsule daily, preferably in the morning on an empty stomach, as co-medication to conventional antimicrobial therapy, until symptoms disappear, for at least 10 days
Administration
- Take in the morning on an empty stomach
- Swallow capsule whole
- Take at the same time each day
Missed dose
Not generally applicable; consult doctor if needed.
Side effects
Common (up to 1 in 10):
- Diarrhea
- Nausea
- Headache
- Stomach problems, gastric intolerance
Uncommon (up to 1 in 100):
- Allergic reaction
- Abdominal pain
- Skin rash, itching
- Fever
Very rare (less than 1 in 10,000):
- Swelling (edema) of the mouth
- Swelling of ankles, feet, or fingers
- Hair loss
Precautions & warnings
- Discontinue if allergic reactions or signs of intolerance occur
- Immunosuppressive drugs may reduce or block efficacy
Contraindications
- Hypersensitivity to constituents of Uro-Vaxom
Drug interactions
Immunosuppressive drugs may reduce or block efficacy.
Food interactions
No food interactions known.
Use in pregnancy
Use in Pregnancy: Avoid use of Uro-Vaxom during pregnancy (especially during the first trimester).
Use in lactation
Use in Lactation: Discuss with your doctor before use during breastfeeding.
Pediatric use
Safety and efficacy not established in children below 4 years.
Geriatric use
Safe for elderly; no special precautions needed.
Renal / hepatic impairment
No specific information for patients with hepatic or renal disorders.
Overdose effects
No cases of overdose observed.
Storage conditions
Store in original package, out of sight and reach of children.
Chemical structure
Lyophilized Bacterial Lysates of E. coli