Generic
Magaldrate
10 brands available in the market
At a glance
Magaldrate is used to relieve symptoms of dyspepsia, heartburn, acid indigestion, gastroesophageal reflux, hiatal hernia, and flatulence. It is also prescribed for hyperacidity associated with peptic ulcers, gastritis, and esophagitis.
Description
Magaldrate is a hydroxymagnesium aluminate complex that is rapidly converted in gastric acid to Mg(OH)2 and Al(OH)3, which are poorly absorbed and provide a sustained antacid effect.
Indications
- Dyspepsia, heartburn, acid indigestion
- Gastroesophageal reflux and hiatal hernia
- Hyperacidity associated with peptic ulcers, gastritis and esophagitis
- Flatulence
Therapeutic class
Antacids, Anti-dyspeptic/Carminatives
Pharmacological class
Antacid
Pharmacology
Magaldrate rapidly neutralizes gastric acid without raising pH above 5-6 and decreases pepsin activity, providing a sustained antacid effect.
Mechanism of action
Neutralizes excess stomach acid.
Dosage
Adult Dose (Oral):
- Mild gastric disorders, gastritis: 1-2 tablets/1-2 teaspoonfuls, 1-2 hours after meals or at bedtime
- Duodenal ulcers, gastric ulcers, reflux oesophagitis: 2-4 tablets/2-4 teaspoonfuls, 1-2 hours after meals or at bedtime
Children: Half of the adult dose
Administration
- Chew tablets; shake suspension well before use
- Measure with a measuring cup and take by mouth
- Take 1-2 hours after meals or at bedtime
Missed dose
Not generally applicable; consult doctor if needed.
Side effects
Common Side Effects:
- Constipation
- Diarrhea
Precautions & warnings
- Caution in decreased kidney function, hypophosphataemia, and weak people
- Inform doctor if signs of appendicitis (lower abdominal pain, cramping, bloating, nausea, vomiting) occur
Contraindications
- Hypersensitivity to magnesium and aluminium
- Impaired renal function
Drug interactions
No significant drug interactions known.
Food interactions
Alcohol consumption with Magaldrate is unsafe.
Use in pregnancy
Use in Pregnancy: May be used if indicated but avoid excessive dosage; consult your doctor.
Use in lactation
Use in Lactation: May pass into breast milk but no problems reported; consult your doctor.
Pediatric use
May be given to children if necessary (half of adult dose).
Geriatric use
Safe for elderly; no special precautions needed.
Renal / hepatic impairment
Renal Impairment: Limited information available; contraindicated in impaired renal function.
Hepatic Impairment: Limited information available; consult your doctor.
Overdose effects
Overdose is rare; excessive amounts may cause diarrhea or constipation.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
Chemical structure
Magaldrate