Generic
Mepyramine Maleate 2% Topical
1 brands available in the market
At a glance
Mepyramine Maleate 2% Topical is an antihistamine cream used for pruritic skin disorders. It blocks histamine receptors to relieve allergic itching and inflammation.
Description
Mepyramine is an ethylenediamine-derived antihistamine with antimuscarinic and sedating properties. It blocks histamine receptors to reduce itching, redness, and inflammation caused by allergic reactions. Topical application provides local action with minimal systemic absorption.
Indications
- Pruritic skin disorders
- Topical/cutaneous hypersensitivity reactions
Therapeutic class
Topical Antihistamine
Pharmacological class
Ethylenediamine Antihistamine
Pharmacology
Mepyramine blocks histamine receptors to reduce allergic itching, redness, and inflammation.
Mechanism of action
Relieves itching and allergic reactions by blocking histamine receptors.
Dosage
Adult Dose (Topical):
- Apply 2% cream on affected areas
- Use as needed
Administration
- For external use only
- Apply a small amount to the affected area
- Do not apply to broken skin
- Avoid contact with eyes
Missed dose
Not generally applicable (use as needed); consult doctor if needed.
Side effects
Common Side Effects:
- Sedation
- Antimuscarinic effects
- CNS depression and disturbances
- Paradoxical CNS stimulation (occasional)
- Psychomotor impairment
- Headache
- Palpitations and arrhythmias
Precautions & warnings
- Caution in pregnancy and lactation
- Caution in severe cardiovascular disorders, asthma, epilepsy
- Caution in angle-closure glaucoma, urinary retention, prostatic hyperplasia
- Caution in renal and hepatic impairment
- Caution in elderly and epileptic patients
- May affect ability to drive and operate machinery
Contraindications
- Severe liver disease
- Premature infants or full-term neonates
- Eczema (topical)
Drug interactions
- Increased effects with CNS depressants (alcohol, barbiturates, hypnotics, opioid analgesics)
- Additive effects with other antimuscarinics (TCAs, atropine)
Food interactions
Alcohol may increase sedative effects with Mepyramine.
Use in pregnancy
Use in Pregnancy: Use with caution during pregnancy; consult your doctor.
Use in lactation
Use in Lactation: Use with caution during lactation; consult your doctor.
Pediatric use
Do not use in premature infants and neonates; consult doctor for children.
Geriatric use
Use with caution in elderly patients.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Caution in liver disease; contraindicated in severe liver disease.
Overdose effects
No specific overdose information available; symptomatic and supportive treatment.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.
Chemical structure
Mepyramine Maleate 2% Topical