Generic
Metronidazole + Miconazole Nitrate
1 brands available in the market
At a glance
Metronidazole + Miconazole Nitrate is a combination medicine used to treat vaginal infections.
Description
Metronidazole + Miconazole Nitrate combines two medicines: Miconazole (antifungal) stops fungal growth and Metronidazole (antibiotic) kills bacteria by damaging DNA.
Indications
- Vaginal trichomoniasis
- Vaginal candidiasis
- Mixed vaginal infections
- Vaginal discharge infections
Pharmacological class
Antifungal + Antibiotic Combination
Pharmacology
Metronidazole is converted to reduction products that interact with DNA causing destruction of helical DNA structure. Miconazole inhibits ergosterol synthesis damaging fungal cell wall membrane.
Mechanism of action
Stops the growth of infection-causing microorganisms.
Dosage
Adult Dose (Vaginal Tablet):
- Trichomoniasis: 1 vaginal tablet daily (at bedtime) for 10 days
- Candidiasis: 1 vaginal tablet daily (at bedtime) for 10 days
Administration
- For external use only
- Insert high up into the vagina (at bedtime)
- Wash hands before and after application
Missed dose
Not applicable (topical preparation)
Drug interactions
Metronidazole: Disulfiram-like reaction with alcohol, increased oral anticoagulant effect, increased phenytoin levels.
Miconazole: Increased bleeding risk with warfarin, increased toxicity of phenytoin and cyclosporine.
Food interactions
Food interaction not found.
Contraindications
- Hypersensitivity to components
- Hepatic impairment
- Porphyria
Side effects
Side Effects:
- Mild irritation and burning at application site
- Redness and itching
- Dry skin
Use in pregnancy
Use in Pregnancy: Possibly unsafe. Your doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Use with caution. Hold breastfeeding until treatment is completed.
Precautions & warnings
- For external use only
- Discontinue if sensitization occurs
- Caution in pregnancy and lactation
Pediatric use
Safety and efficacy in children not established.
Geriatric use
No specific dose adjustment for elderly.
Renal / hepatic impairment
Renal Impairment: No interaction found.
Hepatic Impairment: No interaction found.
Overdose effects
No overdose information available (topical preparation).
Therapeutic class
Drugs used in Vaginal and Vulval conditions
Storage conditions
Store in a cool and dry place. Keep out of reach of children.
Chemical structure
Metronidazole + Miconazole Nitrate