Mitomycin

Mitomycin is used in the treatment of certain kinds of cancer of pancreas, breast, lung, and stomach. It can be used alone or in combination with some medicines as part of combination chemotherapy. It works by interfering with the growth of cancer cells, which are eventually destroyed. Mitomycin is given as an injection into vein under the supervision of a doctor and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include anemia (low number of red blood cells), decreased white blood cell count, increased bleeding tendency, loss of appetite, nausea, and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Before taking this medicine, inform your doctor if you have medical conditions involving blood, kidney, and liver or if you are suffering from any breathing disorder. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Mitomycin is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

• Pancreatic cancer • Breast cancer • Non-small cell lung cancer • Stomach cancer

Mitomycin is an antineoplastic antibiotic which is enzymatically reduced to its active metabolite w/in susceptible cells. The active metabolite appears to cause cross-linking of DNA (primarily w/ guanine and cytosine pairs). It is also active against gm+ve bacteria and some viruses.

Adult Dose: Intravenous Solid tumours The usual dose is in the range of 4-10 mg (0.06-0.15 mg/kg) given at 1-6 weekly intervals depending on whether other drugs are given in combination and on bone marrow recovery. In a number of combination schedules, the dose is 10 mg/m2 of body surface area, the course being repeated at intervals for as long as required. A course ranging from 40-80 mg (0.58-1.2 mg/kg) is often required for a satisfactory response when used alone or in combination. A higher dosage course may be given when used alone or as part of a particular combination schedule and total cumulative doses exceeding 2 mg/kg have been given. Intravesical Superficial bladder tumours In the treatment of superficial bladder tumours the usual dose is 20-40 mg dissolved in 20-40 ml of diluent, instilled into the bladder through a urethral catheter, weekly or three times a week for a total of 20 doses. The dose should be retained by the patient for a minimum of one hour. During this one-hour period the patient should be rotated every 15 minutes to ensure that the Mitomycin-C comes into contact with all areas of the bladder urothelium. When the bladder is emptied in the voiding process, care must be taken to ensure that no contamination occurs locally in the groin and genitalia areas. In the prevention of recurrent superficial bladder tumours, various doses have been used. These include 20 mg in 20 ml of diluent every two weeks and 40 mg in 40 ml of diluent monthly or three monthly. The dose is instilled into the bladder through a urethral catheter. In both cases, the dose should be adjusted in accordance with the age and condition of the patient. Child Dose: Safety and efficacy not established Renal Dose: Renal Impairment Serum creatinine >1.7 mg/dL: Avoid use CrCl <10 mL/min: Decrease dose by 25% CAPD: Decrease dose by 25%

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Anemia (low number of red blood cells) • Decreased white blood cell count • Increased bleeding tendency • Loss of appetite • Nausea • Vomiting • Feeling of discomfort • Low blood platelets • Weight loss • Rash

[UNSAFE] Mitomycin may cause side effects which could affect your ability to drive. Mitomycin may cause nausea and vomiting and thereby reduce your reaction times to such an extent that the ability to drive a motor vehicle is impaired. Inform your doctor if you have any of the following medical conditions: kidney disease; heart disease; or asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder. Before you take mitomycin, inform your doctor if have /are being treated for kidney disease, bleeding disorder or blood disorder. Take precautions as mitomycin can lower the ability of your body to fight infections and the ability of your blood to clot. You may get an infection or bleed more easily. Seek immediate medical attention if you notice any redness, sores, oozing, or other skin changes during or after your treatment with mitomycin. Skin changes can occur several weeks or months after a mitomycin injection. Do not drive or operate machinery as mitomycin may cause weakness and lethargy. Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Hypersensitivity. Patient w/ platelet counts 1.7 mg/dL. Patient w/ substantial prolongation of prothrombin time or bleeding time, coagulation disorders, increased bleeding tendency. Pregnancy and lactation.

Increased incidence of cardiotoxicity w/ doxorubicin. Potentially Fatal: Increased risk of intravascular haemolysis and renal failure w/ fluorouracil. Increased risk of haemolytic uraemic syndrome w/ tamoxifen. Acute pulmonary toxicity w/ vinca alkaloids (e.g. vinblastine, vinorelbine). Increased bone marrow depressant effects of aclarubicin.

[UNSAFE] Mitomycin may cause excessive drowsiness with alcohol.

[UNSAFE] Mitomycin is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[CAUTION] Mitomycin should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

[CAUTION] Mitomycin should be used with caution in patients with kidney disease. Dose adjustment of Mitomycin may be needed. Please consult your doctor. Use of Mitomycin is not recommended in patients with end-stage kidney disease. [CAUTION] Mitomycin should be used with caution in patients with liver disease. Dose adjustment of Mitomycin may be needed. Please consult your doctor. Use of Mitomycin may not be recommended in some patients with liver disease.

I want to know the symptoms of cancer as I am a smoker Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time. What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer. If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON. Metastatic breast cancer, send me previous treatment details I am PATIENT have pain in my breastes and feel very weight before one week of my menstrual perieds date Is it any symptoms of breast cancer ? Need your advice And also having back pain during menstrual dates please give your valubel advice No it&#x27;s not a symptom of breast cancer. I seem to have lung cancer , becoz all the symptoms are same as lung cancer. I test my blood, they suggests me that it is highly probable to lung cancer. Sir what can i do now. This is in preliminary stage Do you think that lung cancer is diagnosed from blood She has breast cancer at 4 sta Dear PATIENT 4 Breast Cancer means that the cancer has spread to other parts of the body. The management of such cancers depends on the site where the cancer has spread and on the receptor status of the breast cancer. If you can share the details with me, I will be happy to let you know the potential management Please see the attached file Doctor U will need medicines but right now priority is treating lung cancer