Moxonidine

Moxonidine is a medicine used in the treatment of hypertension (high blood pressure). It lowers the blood pressure by relaxing the blood vessels. Lowering the blood pressure helps to prevent future stroke and heart attack. Moxonidine can be taken with or without food. You can take it at any time of day but try to take it at the same time each day. You should take this medicine as advised by the doctor and never stop it abruptly without consulting the doctor. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your blood pressure rising up again and increase your risk of heart disease and stroke. It is important to have your blood pressure checked regularly. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake and weight reduction. You can eat normally while taking this medicine, but try to reduce your salt intake. Common side effects of this medicine include dry mouth, nausea, dizziness, headache, insomnia and back pain. Consult your doctor if these side effects bother you. Before taking this medicine, its better to let your doctor know if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should consult doctor before taking it. Moxonidine is an anti-hypertensive medication. It works by relaxing blood vessels which makes the heart more efficient at pumping blood around the body.

• Hypertension (high blood pressure)

Moxonidine is a centrally-acting antihypertensive. It acts in the brainstem through stimulation of central imidazoline receptors to reduce sympathetic tone. Moxonidine also has a low affinity for alpha2-adrenoceptors.

Adult Dose: Oral Hypertension Adult: 200 mcg once daily, increase if necessary after 3 wk to 400 mcg daily as single or in 2 divided doses. If necessary, after a further 3 wk, increase to 600 mcg daily in 2 divided doses. Max: 600 mcg daily. Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation 30-60 Single dose should not exceed 200 mcg. Max daily dose 400 mcg. <30 Avoid

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Moxonidine may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Moxonidine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Dryness in mouth • Headache • Rash • Dizziness • Back pain • Insomnia (difficulty in sleeping) • Sleepiness • Vomiting • Weakness • Nausea • Diarrhea • Vertigo

[UNSAFE] Moxonidine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Moxonidine lowers your blood pressure and makes it easier for your heart to pump blood around your body. Lowering high blood pressure helps prevent stroke and heart attack. Eat healthy (low-sodium diet), exercise, quit smoking, limit alcohol intake, and reduce stress along with taking Moxonidine. Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help. Moxonidine may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. It may cause you to feel lightheaded especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down.

Conduction disorders; bradycardia; severe arrhythmias; severe heart failure; severe ischaemic heart disease; history of angioedema; severe liver or renal impairment; Raynaud's syndrome; intermittent claudication; epilepsy; depression; Parkinson's disease; glaucoma. Pregnancy and lactation.

Additive effects with other antihypertensives; may increase sedative effects of benzodiazepines. Effects may be antagonised by TCAs.

[UNSAFE] Moxonidine may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Moxonidine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Moxonidine during breastfeeding is not available. Please consult your doctor.

[CAUTION] Moxonidine should be used with caution in patients with kidney disease. Dose adjustment of Moxonidine may be needed. Please consult your doctor. [CAUTION] Moxonidine should be used with caution in patients with severe liver disease. Dose adjustment of Moxonidine may be needed. Please consult your doctor. Use of Moxonidine is not recommended in these patients.

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