Naltrexone

Naltrexone is used in the treatment of opioid dependence and alcohol addiction. It works by blocking the euphoric feelings (highs) that Some people may experience after taking opiates and alcohol. This reduces the craving and helps you stay away from them. Naltrexone may be taken with or without food. Take it regularly at a fixed time each day to get the maximum benefit of the medicine. Using of Naltrexone may cause side effects such as tiredness, nausea, vomiting, abdominal pain, joint pain and diarrhea. Do not drive or operate machinery after taking the medicine as you may feel dizzy or tired. Naltrexone is an opioid antagonist. It works by blocking the euphoric feelings (highs) that you may experience after taking opiates and alcohol. This reduces craving and helps you remain off of them.

• Opioid dependence • Alcohol addiction

Naltrexone acts as a competitive antagonist at opioid receptor sites. It blocks the action of opioids and precipitates withdrawal symptoms in opioid-dependent individuals.

Adult Dose: Opioid Dependence Prevention of relapse after opioid detoxification; to be used only after patient has been opioid-free for 7-10 days and after negative naloxone challenge (no symptom withdrawal after naloxone administration) PO: 25 mg initially, then observation for 1 hr, then 50 mg once daily starting on day 2; flexible dosing regimens can be employed to accommodate patient convenience or ensure compliance IM: 380 mg in gluteal muscle every 4 weeks for maintenance of abstinence Alcohol Dependence Treatment in patients who have been able to abstain from alcohol in outpatient settings before treatment initiation PO: 50 mg once daily for <12 weeks IM: 380 mg in gluteal muscle every 4 weeks for maintenance of abstinence Child Dose: Safety and efficacy not established

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naltrexone may be taken with or without food, but it is better to take it at a fixed time.

Common: • Joint pain • Fainting • Decreased libido • Muscle pain • Insomnia (difficulty in sleeping) • Increased thirst • Decreased sexual function

[UNSAFE] Naltrexone may cause side effects which could affect your ability to drive. Naltrexone may make you feel tired or dizzy. This may affect your driving ability. Take it at the same time every day to help you remember to take it. Do not consume opioid derivatives while on this treatment. Do not drive or do anything requiring concentration until you know how Naltrexone affects you. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you are pregnant, planning to become pregnant or are breastfeeding.

Patients concurrently dependent on opioids; acute hepatitis or hepatic failure; acute opioid withdrawal; patients on therapeutic opioid analgesics.

May reduce effects of opiate-containing preparations e.g. those used for cough and cold, diarrhoea and pain. Increased or decreased serum levels with drugs that alter hepatic metabolism. Potentially increased hepatotoxic effects with disulfiram. Increased risk of naltrexone-induced lethargy and somnolence with thioridazine. May increase insulin requirements.

[SAFE] Consuming alcohol with Naltrexone does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Naltrexone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Naltrexone is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Naltrexone should be used with caution in patients with kidney disease. Dose adjustment of Naltrexone may be needed. Please consult your doctor. [CAUTION] Naltrexone should be used with caution in patients with liver disease. Dose adjustment of Naltrexone may be needed. Please consult your doctor. Regular monitoring of liver function tests is advisable while you are taking this medicine.

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