Generic
Oral rehydration salt [glucose based]
38 brands available in the market
At a glance
Oral rehydration salt [glucose based] is used to replace fluid and electrolyte loss due to acute diarrhea, vomiting and dehydration. It is effective for prevention and treatment of dehydration in all age groups.
Description
ORS contains sodium chloride, potassium chloride, trisodium citrate dihydrate and anhydrous glucose. Glucose enhances sodium and water absorption in the intestine, helping prevent dehydration.
Indications
- Replacement of fluid and electrolyte loss due to acute diarrhea
- Replacement of fluid and electrolyte loss due to vomiting
- Prevention and treatment of all types of dehydration
Therapeutic class
Oral Electrolyte Preparations
Pharmacological class
Rehydration Salt
Pharmacology
Glucose in ORS activates sodium-glucose co-transporter (SGLT1) in the intestinal brush border membrane to enhance sodium and water absorption, helping replace water and electrolyte loss during diarrhea.
Mechanism of action
Prevents dehydration by replacing water and electrolyte loss during diarrhea and vomiting.
Dosage
Prevention and Treatment of Dehydration:
- Give equal amount of ORS after each loose motion or vomiting
- Children below 2 years: 50-100 ml (10-20 teaspoonfuls) prepared saline
- Children 2-10 years: 100-200 ml (0.5-1 glass) prepared saline
- Children above 10 years and adults: 200-400 ml (1-2 glasses) prepared saline
Administration
- Dissolve 1 sachet in 500 ml of pure drinking water
- Do not use hot water
- Do not heat the mixture
- Use within 12 hours of preparation
Missed dose
Not generally applicable (take as needed); consult doctor if needed.
Side effects
Side Effects:
- No side effects when prepared and used correctly
Precautions & warnings
- Severe continuing diarrhea or critical fluid loss may need parenteral fluids
- Caution in depressed renal function
Contraindications
No known contraindications.
Drug interactions
No known drug interactions.
Food interactions
Take with food for better absorption.
Use in pregnancy
Use in Pregnancy: Safe and beneficial during pregnancy.
Pregnancy Category: A — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safe and beneficial during lactation.
Pediatric use
Safe and indicated for children of all ages.
Geriatric use
Safe for all ages.
Renal / hepatic impairment
Renal Impairment: Depressed renal function may need parenteral fluids; monitor potassium levels.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed.
Overdose effects
Overdose may cause electrolyte imbalance; symptomatic treatment.
Storage conditions
Do not store above 30°C; keep away from light and wet places; keep out of reach of children.
Chemical structure
Glucose-based Oral Rehydration Salt