Pentoxifylline

Pentoxifylline is used to treat peripheral vascular disease (poor circulation to the arms and legs) and intermittent claudication (pain on walking or at rest caused by poor circulation to the legs). It works by increasing the blood flow to the arms and legs. Pentoxifylline reduces cramping in the legs that occur on walking in such patients. It also has beneficial effects in alcohol-related liver damage. This medicine should be taken regularly as advised by the doctor. You should take it with food and at a fixed time. You should never stop it abruptly without consulting the doctor. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, and smoking cessation. It may cause side effects like nausea, vomiting, diarrhea, headache, flushing (sense of warmth in the face, ears, neck, and trunk), and weakness. This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Pentoxifylline is a peripheral vasodilator. It works by decreasing the thickness (viscosity) of blood, allowing it to pass more easily through the blood vessels. This effect is beneficial in peripheral vascular disease, where the blood vessels in the arms and legs are narrowed.

• Peripheral vascular disease • Intermittent claudication

Pentoxifylline reduces blood viscosity by increasing deformability of leukocytes and erythrocytes; and decreasing neutrophil adhesion/activation. It also improves microcirculation and peripheral tissue oxygenation through better blood flow. It has also been used in cerebrovascular disorders.

Adult Dose: Oral Peripheral vascular disease Adult: As modified-release formulation: 400 mg tid (normally for at least 8 wk) May reduce to 400 mg bid if GI or CNS adverse effects occur. Intermittent Claudication 400 mg PO q8hr Recommended duration of treatment: >8 weeks Hepatic impairment: Dose reduction may be needed in severe impairment. Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Moderate impairment (CrCl about 60 ml/min): 400 mg bid; Severe impairment (CrCl about 20 ml/min): 400 mg once daily; may reduce further to 400 mg once every other day if needed.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pentoxifylline is to be taken with food.

If you miss a dose of Pentoxifylline, skip it and continue with your normal schedule. Do not double the dose.

Common: • Bloating • Diarrhea • Flushing (sense of warmth in the face, ears, neck and trunk) • Headache • Heartburn • Lightheadedness • Nausea • Stomach discomfort • Vomiting • Weakness

[UNSAFE] Pentoxifylline may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Take it as per dose and duration suggested by your doctor. Take it with or without food. Do not drive or perform activities that require mental focus until you know how Trental 400 Tablet ER affects you. Your doctor may get regular blood tests done to monitor liver function while taking this medicine. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Previous hypersensitivity reactions to xanthine-related products e.g. caffeine, theophylline and theobromine. Recent cerebral and/or retinal haemorrhage. Porphyria.

Concurrent use with ciprofloxacin may increase the adverse effect of pentoxifylline. Concurrent use may increase serum levels of theophylline derivatives. Potentially Fatal: May increase risk of adverse effect when used with ketorolac.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Pentoxifylline. Please consult your doctor.

[CONSULT YOUR DOCTOR] Pentoxifylline may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Pentoxifylline is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Pentoxifylline should be used with caution in patients with kidney disease. Dose adjustment of Pentoxifylline may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Pentoxifylline in patients with liver disease. Please consult your doctor.

I have been prescribed Trental 400 mg.How long should l take Trental 400 mg under prescription ? duration depends on the the reason for giving this medicine Type II diabetic patient having foot pain with blood clotting. The prescribed tab TRENTAL 400 is not available in market. FBS-218, RBS-313 Trental is available in the market. Try with some other chemist shop. You needs to take diabetic medicine. What is medicine for claudication Please consult a vascular surgeon Having diabetes ,hypertension amd joint pain since past 5-6 yr by medication diabetes and hyoertension are controlled but peripheral neuropathy of both lower limb also associated with peripheral vascular disease of lower limbs best treatmrnt where and from which departnent?? A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED. ALWAYS IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you SHOULD not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET I am geting pain on my left leg After taking pain killer. Feeling gud but after stop pain killer again. Same pain One of the veins geting pain Please visit a surgeon, you may need a venous Doppler to identify any vascular claudication or any other pathology. Once ruled out, psychological issues can be explored. Which tablet she can have in her leg there is water and she is unable to walk Get peripheral Doppler done During winter, I have acute problem of Blood circulation in leg, as a result, toe gets swellied and finally soars develops. Find, Trental-400Mg is effective for this probelm. But it's not available anywhere, also it's substitutes are also not available. Kindly sugest This can be chillblain Use gloves and warm water to reduce these problems Other medicines can be given bt only after checking few parameters Plz visit a nearby dermatologist and also take opinion form a cardiovascular surgeon to rule out any arterial obstruction Sir, madam I have been suffering from pain in my right ankle accompanied by swelling. I could also feel the pain in my hips as well. I suspect this to be peripheral vascular disease, since i frequently get the cramp whenever I walk or do physical activity in my right ankle.I only feel relieved when I take tablets like Pynor. Please suggest some suggest medication. Thank you. You better consult once with an Ayurvedic physician in person before starting the treatment