Generic
Pseudoephedrine + Triprolidine
1 brands available in the market
At a glance
Pseudoephedrine + Triprolidine is a combination medicine used for relief of common cold symptoms such as runny nose, stuffy nose, sneezing, watery eyes, and congestion. Pseudoephedrine is a decongestant that narrows small blood vessels to relieve nasal congestion, and Triprolidine is an antiallergic that relieves allergy symptoms.
Description
Pseudoephedrine is an alpha- and beta-adrenergic receptor agonist that causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa, reducing nasal congestion. Triprolidine hydrochloride is a potent competitive H1-receptor antagonist with antimuscarinic and mild sedative properties, relieving allergy symptoms.
Indications
- Common cold symptoms (runny nose, stuffy nose, sneezing, watery eyes, congestion)
Therapeutic class
Decongestant + Antihistamine Combination
Pharmacological class
α-Adrenergic Agonist + H1 Antagonist
Pharmacology
Pseudoephedrine stimulates alpha-adrenergic receptors of the respiratory mucosa, causing vasoconstriction and reducing nasal mucosal swelling and congestion. Triprolidine blocks H1 receptors, preventing histamine effects and relieving allergy symptoms (runny nose, sneezing, watery eyes).
Mechanism of action
Relieves cold symptoms by constricting nasal blood vessels and blocking histamine.
Dosage
Adult Dose (Oral):
- Allergic rhinitis/Cold and flu: 1 tablet every 4-6 hours, up to 4 times daily
Pediatric Dose (Oral):
- >12 years: Same as adult
Administration
- May be taken with or without food; take at a fixed time
- Measure with a measuring cup; shake well before use
Missed dose
If you miss a dose, take it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Common Side Effects:
- Nausea
- Stomach discomfort
- Headache
- Nervousness
- Restlessness
- Insomnia
- Dizziness
- Drowsiness
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Avoid alcohol (excessive drowsiness)
- Do not use in severe hypertension, coronary artery disease, or with or within 2 weeks of MAOIs
- Caution in kidney or liver disease
Contraindications
- Concurrent use or within 2 weeks of stopping MAOIs
- Severe hypertension or coronary artery disease
Drug interactions
- Other sympathomimetics (decongestants, TCAs, appetite suppressants): Increased blood pressure
- Methyldopa, beta-blockers: Reduced hypotensive effects
- Atomoxetine: Increased side effects (somnolence, agitation)
- Potentially fatal: Hypertensive crisis with furazolidine; hypertensive crisis with MAOIs; increased risk of psychosis with bromocriptine
Food interactions
It is not known whether it is safe to consume alcohol with Pseudoephedrine + Triprolidine.
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Probably safe; limited human data suggests no significant risk.
Pediatric use
Safety not established in children under 12 years.
Geriatric use
Caution required in elderly patients; dose adjustment may be needed.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed; not recommended in severe kidney disease; consult your doctor.
Hepatic Impairment: Caution in severe liver disease; dose adjustment may be needed; consult your doctor.
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store in a cool and dry place; keep out of reach of children.
Chemical structure
Pseudoephedrine + Triprolidine