Generic
Salmeterol + Fluticasone
81 brands available in the market
At a glance
Salmeterol + Fluticasone is a combination inhaler used for the regular treatment of asthma and COPD. Salmeterol acts as a bronchodilator and fluticasone as a corticosteroid to reduce inflammation.
Description
Salmeterol + Fluticasone is a combination of a long-acting β2-agonist (salmeterol) and an inhaled corticosteroid (fluticasone). Salmeterol relaxes bronchial smooth muscles; fluticasone provides potent glucocorticoid anti-inflammatory action in the lungs, reducing asthma symptoms and exacerbations.
Indications
- Regular asthma treatment (where combination therapy is appropriate)
- COPD maintenance
Therapeutic class
Long-acting β2-Agonist + Inhaled Corticosteroid
Pharmacological class
Bronchodilator + Corticosteroid
Pharmacology
Salmeterol stimulates β2-receptors, relaxing bronchial smooth muscles; fluticasone controls inflammation by inhibiting inflammatory cells and mediators in the lungs. This dual action provides long-term bronchodilation and inflammation control.
Mechanism of action
Relaxes airways and controls inflammation to manage asthma and COPD.
Dosage
Adults and Adolescents (≥12 years):
- Inhaler: 2 puffs of 25 µg+50/125/250 µg twice daily
- Inhalation capsule (Asthma): 50 µg+100/250 µg twice daily
- Inhalation capsule (COPD): 50 µg+250 µg twice daily
Children (4-12 years):
- Inhaler: 2 puffs of 25 µg+50 µg twice daily
- Inhalation capsule: 50 µg+100 µg twice daily
Administration
- Inhalation only; do not swallow capsules
- Shake well (at least 6 times) before each use
- Rinse mouth after each inhalation
- Take at the same time each day
Missed dose
If you miss a dose, take the next dose at the scheduled time; do not double the dose.
Side effects
Common Side Effects:
- Oropharyngeal candidiasis (fungal infection)
- Throat pain and hoarseness
- Headache
- Tremor and palpitations
- Musculoskeletal pain
- Respiratory tract infection
Precautions & warnings
- Do not use for acute asthma or COPD attacks
- Always carry a fast-acting reliever inhaler
- Paradoxical bronchospasm may occur; discontinue if occurs
- Risk of pneumonia (in COPD patients)
- Long-term high doses may cause adrenal suppression, growth retardation, cataracts, glaucoma
Contraindications
- Hypersensitivity to any component
- Status asthmaticus or acute asthma attacks
- Severe hypersensitivity to milk proteins
Drug interactions
- CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole): Increased fluticasone exposure
- Other β-agonists: Additive effects
- β-blockers: Decreased efficacy and bronchospasm
Food interactions
It is not known whether alcohol is safe with Salmeterol + Fluticasone; consult your doctor.
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Probably safe; limited human data suggests no significant risk; consult your doctor.
Pediatric use
Indicated for children 4-12 years; inhaled corticosteroids may reduce growth velocity
Geriatric use
No overall differences in safety or effectiveness observed in elderly vs. younger patients
Renal / hepatic impairment
Renal Impairment: No dose adjustment needed; consult your doctor.
Hepatic Impairment: No data available for use in hepatic impairment; consult your doctor.
Overdose effects
Salmeterol overdose: Seizures, angina, hypertension/hypotension, tachycardia, hypokalemia; Fluticasone overdose: Adrenal suppression.
Storage conditions
Store below 30°C, protected from light; do not puncture or incinerate canister; keep out of reach of children.
Chemical structure
Salmeterol + Fluticasone