Generic
Silymarin + DL-Alpha Tocopherol
2 brands available in the market
At a glance
Silymarin + DL-Alpha Tocopherol is a herbal supplement used for the prevention and treatment of liver diseases (alcoholic and non-alcoholic), fatty liver, hepatitis, liver cirrhosis, jaundice, liver fibrosis, and drug-induced hepatotoxicity.
Description
Silymarin is a flavonoid complex from Milk Thistle that acts as a hepatoprotective agent. It stimulates RNA polymerase-A, enhances protein synthesis, stabilizes liver cell membranes to prevent toxin entry, and exhibits anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, and immunomodulatory effects. Vitamin E is a powerful antioxidant that protects cells from oxidative damage.
Indications
- Liver disease (alcoholic and non-alcoholic)
- Fatty liver (alcoholic and non-alcoholic)
- Hepatitis
- Liver cirrhosis (alcoholic and non-alcoholic)
- Jaundice
- Liver fibrosis
- Drug-induced hepatotoxicity
Therapeutic class
Herbal and Nutraceuticals
Pharmacological class
Hepatoprotective & Antioxidant
Pharmacology
Silymarin stimulates RNA polymerase-A, enhancing protein synthesis, stabilizes liver cell membranes to prevent toxin entry, and exhibits anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, and immunomodulatory effects. Vitamin E acts as a powerful antioxidant, protecting cells from oxidative damage and supporting liver regeneration.
Mechanism of action
Restores liver cells, prevents toxin entry, and acts as an antioxidant.
Dosage
Dosage:
- 1 tablet twice daily
- Take as directed by a physician
Administration
- Take orally with or without food
- Take as directed by a physician
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for the next dose, skip it; do not double the dose.
Side effects
Side Effects:
- Well tolerated at recommended doses
- Occasional mild laxative effect may occur
Precautions & warnings
- Do not use if hypersensitive to silymarin or vitamin E
- Consult a doctor during pregnancy and lactation
Contraindications
- Known hypersensitivity to silymarin or vitamin E
Drug interactions
- Concomitant use with butyrophenones or phenothiazines may reduce lipid peroxidation
Food interactions
Caution is advised when consuming alcohol with Silymarin + DL-Alpha Tocopherol; consult your doctor.
Use in pregnancy
Use in Pregnancy: Adequate information not available; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Adequate information not available; consult your doctor.
Pediatric use
Safety and efficacy not established in children
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Caution needed; consult your doctor.
Hepatic Impairment: Effective in liver disease; caution needed in severe liver disease; consult your doctor.
Overdose effects
No overdose information available; consult your doctor if overused.
Storage conditions
Store in a cool and dry place, away from light and moisture; keep out of reach of children.
Chemical structure
Silymarin + DL-Alpha Tocopherol