Sodium picosulfate

Sodium picosulfate is a medicine used to treat constipation. It is a laxative and helps you empty your bowels. It works by increasing movement in the intestine and provides relief from constipation. Sodium picosulfate should be taken in a dose as advised by your doctor and take it at a fixed time at night. You should not use this medicine for more than a few days unless your doctor tells you to. Some lifestyle changes can help with constipation, for example eating more fibre in foods such as fruit, vegetables and cereals, drinking plenty of fluids and taking regular exercise. The most common side effects of taking this medicine are headache, nausea and vomiting. These are usually mild and go away after a couple of days. If they persist, your doctor may suggest ways of preventing or reducing them. Before using this medicine you should tell your doctor if you have a blockage in your bowel, upset stomach or your bowel movements have been different for more than two weeks. Sodium picosulfate is a laxative. It works by increasing the movement of the intestines, thereby facilitating the passage of stool.

Bacterial infections (Respiratory tract infections, Skin infections, Soft tissue infections, Pelvic Inflammatory Disease (PID), Gonorrhea, Syphilis, Acne, Rheumatic fever, Bacterial endocarditis prophylaxis)

Macrolide Antibiotics

Protein Synthesis Inhibitor (50S ribosomal subunit)

Erythromycin binds irreversibly to the 50S ribosomal subunit of bacteria, blocking transpeptidation. This prevents the synthesis of essential proteins required for bacterial growth and survival.

Sodium picosulfate is a locally acting laxative which has a dual action of stimulating the mucosa of both the large intestine causing colonic peristalsis and of the rectum causing increased motility and a feeling of rectal fullness.

Adult Dose: Oral Constipation Adult: 5-10 mg as a single dose, usually at bedtime. Bowel evacuation before investigational procedures Adult: 10 mg, w/ Mg citrate, given in the morning and again in the afternoon of the day before examination. Child Dose: Oral Constipation Child: 1 mth to 10 yr 5-10 mg. Doses are usually given at night. Bowel evacuation before investigational procedures Child: 1 mth to 10 yr 5-10 mg. Doses are usually given at night.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sodium picosulfate may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Sodium picosulfate, skip it and continue with your normal schedule. Do not double the dose.

Common: • Vomiting • Headache • Nausea

[CONSULT YOUR DOCTOR] It is not known whether Sodium picosulfate alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Together with Sodium picosulfate, taking a fiber-rich diet containing whole grain bread and cereals, bran, fruits and green leafy vegetables, is essential to maintain healthy bowel function. Avoid taking a Sodium picosulfate for more than 1 week, unless prescribed by the doctor, as it leads to dependency on the laxative action to produce a bowel movement. Take Sodium picosulfate after 2 hours from other medicines, as it may interfere with the absorption of other medicines. Sodium picosulfate should be preferably taken at bedtime because it requires 6 to 8 hours to show impact.

Acute inflammatory bowel diseases, severe dehydration, ileus or intestinal obstruction, severe painful and/or feverish acute abdominal conditions (e.g. appendicitis) potentially associated w/ nausea and vomiting.

Increased risk of electrolyte imbalance w/ diuretics or adreno-corticosteroids. Increased sensitivity to cardiac glycosides resulting from electrolyte imbalance. Reduced laxative action w/ antibiotics.

[UNSAFE] It is unsafe to consume alcohol with Sodium picosulfate.

[SAFE IF PRESCRIBED] Sodium picosulfate is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Sodium picosulfate is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Safe in children; dosage is 50mg/kg/day based on body weight.

Use with caution; dose adjustment may be needed for kidney/liver function changes.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Sodium picosulfate in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Sodium picosulfate in patients with liver disease. Please consult your doctor.

May cause severe nausea, vomiting, and hearing loss. Seek medical help immediately.

Store below 30°C, away from light and moisture. Keep out of reach of children.

Molecular Formula: C37H67NO13