Tibolone

Tibolone is a female sex hormone (estrogen). This is a type of hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness, and itching), estrogen deficiency, and thinning of bones (osteoporosis). Tibolone can be taken with or without food, but better to take it at a fixed time each day for better efficacy. It should be swallowed whole with water. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed a dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine. The most common side effects of this HRT are abnormal hair growth, breast tenderness, abdominal cramps or bloating, vaginal bleeding or spotting, nausea, vomiting, and hair loss. Some of the warning signs and symptoms that need immediate medical attention are breast lumps, unusual vaginal bleeding, dizziness and faintness, severe headaches, chest pain, shortness of breath, pains in your legs, etc. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body. Tibolone is a hormonal medication. It has effects similar to estrogen, progesterone and androgen. It substitutes for the loss of estrogen production in postmenopausal women and treats menopausal symptoms such as hot flashes, night sweats and vaginal problems. It also prevents bone loss following menopause.

• Hormone replacement therapy • Post menopausal osteoporosis

Tibolone is a steroid that possesses oestrogenic, progestogenic and weak androgenic properties.

Adult Dose: Oral Menopausal vasomotor symptoms; Adult: 2.5 mg daily. Symptomatic relief occurs within few days, but optimal results are obtained minimum after 3 months. Prophylaxis of postmenopausal osteoporosis Adult: 2.5 mg daily. To prevent osteoporosis in post-menopausal women or after oophorectomy an uninterrupted longer (5-10 years) therapy is needed. Starting Tibolone: In case of natural menopause: To avoid irregular & abnormal bleeding, Tibolone should be started at least 12 months after last natural bleeding. In case of artificial menopause: Treatment should be started immediately. In case of switching over from other conventional HRT: If someone switches from estrogen-only preparation, she should start after a withdrawal bleeding. If someone switches from sequential HRT preparation she should wait for the completion of the progestogen phase. If someone switches from continuous combined HRT, she can start any time. In case of missed pill: If no more than 12 hours have passed, the pill should be taken immediately. Otherwise the next dose should be continued as before.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tibolone may be taken with or without food, but it is better to take it at a fixed time.

Common: • Breast pain • Stomach pain • Vaginal bleeding • Vaginal inflammation • Vaginal spotting • Irritation • Itching • Weight gain

[SAFE] Tibolone does not usually affect your ability to drive. Tibolone is used as a part of hormone replacement therapy to relieve symptoms of menopause such as hot flushes, vaginal dryness, depression, and night sweats. It may also be used for preventing osteoporosis in women who have attained menopause and are at high risk of fractures. Take it at the same time everyday to help you remember to take it. It may cause bleeding or spotting in between menstrual periods. Let your doctor know if this occurs frequently. Stop taking Tibolone and inform your doctor immediately if you get severe headaches, stabbing pains or swelling in one leg, and pain on breathing. These could be symptoms of a blood clot in a vein. Ensure that you regularly check your breasts for any changes and undergo regular breast screening and cervical smear tests while on treatment with this medicine. Do not use Tibolone if you have a history of blood clots and liver disease.

Known or suspected oestrogen dependent tumours in women, present or history of breast cancer, undiagnosed vaginal bleeding, severe liver disease, history or current CV or cerebrovascular disorders, untreated endometrial hyperplasia, porphyria, pregnancy and lactation, premenopausal women.

Enzyme inducers eg, barbiturates, phenytoin, carbamazepine and rifampicin may accelerate tibolone metabolism. Increased anticoagulant effects of warfarin.

[UNSAFE] It is unsafe to consume alcohol with Tibolone.

[UNSAFE] Tibolone is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[CONSULT YOUR DOCTOR] Information regarding the use of Tibolone during breastfeeding is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Tibolone in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Tibolone in patients with liver disease. Please consult your doctor.

I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement. Having urine burning problem past month. with the homeop medicine 70% relief i got. now i stopped medicine to have. five year back hystectomy done overies still remain. due to computer work eyes get dried and tired. shoulders also pain. past 1.7 year back pain started. some time hot flashes also come suddenly. all blood investigation and u/s are normal. as per dr. advise take sweet less. hair fall are more. no dandruff. It is normal to have hot flashes and these post menopausal symptoms after hysterectomyYou can take hormone therapy if you want however symptoms will recurrent when you stop treatment Hello Dr. My mother is 63 years old and her weight is appx. 68 kg. She is suffering from osteoporosis arthritis. I consult to many doctors all suggest me for joint replacement. I want to know, is joint replacement is successful treatment in such age group. yes, you can go for bone replacement therapy. there is no harm in it. Ovaries taken out chest pain and intense sweat high heart beats These are the symptoms of menopause. Consult a gynaec nearby and discuss about post menopausal therapy I had hot flash, sweating and ganrahat Seems like post menopausal syndrome. Visit a gynaecologist. Male hormone testosterone is found less in the recent blood test around 270,shall I take hormone therapy like tablet cents regularly what will be the dose and limitations in use Hi Kindly consult to Allopathic doctor Need physio therapy post Knee surgery Contact nearest i am from lucknow Hello Dr. My mother is 63 years old and her weight is appx. 68 kg. She is suffering from osteoporosis arthritis. I consult to many doctors all suggest me for joint replacement. I want to know, is joint replacement is successful treatment in such age group. Dear sir it depends from case to case.