Generic
Tioconazole 1% Topical
3 brands available in the market
At a glance
Tioconazole 1% Topical Cream is an azole antifungal used for skin fungal infections and pityriasis versicolor. It destroys fungal cell membranes by inhibiting ergosterol synthesis.
Description
Tioconazole is a synthetic azole antifungal that interferes with ergosterol synthesis, needed for fungal cell membrane synthesis. It exhibits fungicidal activity in vitro against Candida albicans, other Candida species, and Torulopsis glabrata.
Indications
- Skin fungal infections (tinea corporis, cruris, manuum, pedis)
- Pityriasis versicolor (tinea versicolor)
- Dermal candidiasis
- Erythrasma (due to activity against some Gram-positive bacteria)
Pharmacological class
Azole Antifungal
Pharmacology
Tioconazole inhibits ergosterol synthesis, disrupting fungal cell membrane integrity. Ergosterol is an essential component of fungal cell membranes; its deficiency increases membrane permeability and causes fungal cell death.
Mechanism of action
Destroys fungal cell membranes by inhibiting ergosterol synthesis.
Dosage
Adult and Pediatric Dose (Topical):
- Skin fungal infections: Apply 1% cream 1-2 times daily to affected area
- Chronic hyperkeratotic tinea pedis may require up to 6 weeks
Administration
- For external use only
- Clean and dry the affected area before application
- Avoid contact with eyes
- Wash hands after application
Missed dose
If you miss an application, apply at the next scheduled time.
Drug interactions
No significant drug interactions known.
Food interactions
Alcohol consumption is not relevant (topical application).
Contraindications
- Hypersensitivity to imidazole-derivative azole antifungals
Side effects
Common Side Effects:
- Contact dermatitis
- Burning, irritation
- Itching
Use in pregnancy
Use in Pregnancy: Adequate information not available; caution required; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Adequate information not available; caution required; consult your doctor.
Precautions & warnings
- For external use only
- Caution in pregnancy and lactation
- Do not use in hypersensitivity to imidazole-derivative azole antifungals
Pediatric use
Indicated for children (with dose adjustment)
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Not applicable (topical application)
Hepatic Impairment: Not applicable (topical application)
Overdose effects
Overdose is not applicable (topical application); excessive use may cause skin irritation.
Therapeutic class
Topical Antifungal Preparations
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
Chemical structure
Tioconazole 1%