Generic
Tioconazole 1% Topical
3 brands available in the market
At a glance
Tioconazole 1% Topical Cream is an azole antifungal used for skin fungal infections and pityriasis versicolor. It destroys fungal cell membranes by inhibiting ergosterol synthesis.
Description
Tioconazole is a synthetic azole antifungal that interferes with ergosterol synthesis, needed for fungal cell membrane synthesis. It exhibits fungicidal activity in vitro against Candida albicans, other Candida species, and Torulopsis glabrata.
Indications
- Skin fungal infections (tinea corporis, cruris, manuum, pedis)
- Pityriasis versicolor (tinea versicolor)
- Dermal candidiasis
- Erythrasma (due to activity against some Gram-positive bacteria)
Therapeutic class
Topical Antifungal Preparations
Pharmacological class
Azole Antifungal
Pharmacology
Tioconazole inhibits ergosterol synthesis, disrupting fungal cell membrane integrity. Ergosterol is an essential component of fungal cell membranes; its deficiency increases membrane permeability and causes fungal cell death.
Mechanism of action
Destroys fungal cell membranes by inhibiting ergosterol synthesis.
Dosage
Adult and Pediatric Dose (Topical):
- Skin fungal infections: Apply 1% cream 1-2 times daily to affected area
- Chronic hyperkeratotic tinea pedis may require up to 6 weeks
Administration
- For external use only
- Clean and dry the affected area before application
- Avoid contact with eyes
- Wash hands after application
Missed dose
If you miss an application, apply at the next scheduled time.
Side effects
Common Side Effects:
- Contact dermatitis
- Burning, irritation
- Itching
Precautions & warnings
- For external use only
- Caution in pregnancy and lactation
- Do not use in hypersensitivity to imidazole-derivative azole antifungals
Contraindications
- Hypersensitivity to imidazole-derivative azole antifungals
Drug interactions
No significant drug interactions known.
Food interactions
Alcohol consumption is not relevant (topical application).
Use in pregnancy
Use in Pregnancy: Adequate information not available; caution required; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Adequate information not available; caution required; consult your doctor.
Pediatric use
Indicated for children (with dose adjustment)
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Not applicable (topical application)
Hepatic Impairment: Not applicable (topical application)
Overdose effects
Overdose is not applicable (topical application); excessive use may cause skin irritation.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
Chemical structure
Tioconazole 1%