Generic
Tobramycin Eye Prep
25 brands available in the market
At a glance
Tobramycin Eye Prep is an aminoglycoside antibiotic used for bacterial eye infections (e.g., conjunctivitis) and eyelid infections (e.g., blepharitis). It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Description
Tobramycin is an aminoglycoside antibiotic that binds to the 30S ribosomal subunit, interfering with bacterial protein synthesis. It is active against many aerobic Gram-negative bacteria and some aerobic Gram-positive bacteria but inactive against Chlamydia, fungi, viruses, and most anaerobic bacteria.
Indications
- Bacterial eye infections (conjunctivitis)
- Eyelid infections (blepharitis)
- Prevention of infection after eye injury or surgery
Therapeutic class
Aminoglycosides, Ophthalmic Antibacterial Drugs
Pharmacological class
Aminoglycoside Antibiotic
Pharmacology
Tobramycin binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis and preventing bacterial growth and spread. It is effective against Pseudomonas aeruginosa, E. coli, Staphylococcus aureus, Streptococcus pneumoniae, and many other bacteria.
Mechanism of action
Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Dosage
Adult and Pediatric (>1 year) Dose (Ophthalmic):
- Mild-moderate infections: 1-2 drops in affected eye(s) every 4 hours
- Severe infections: 2 drops in affected eye(s) every 30-60 minutes until improvement, then reduce frequency gradually
- Eye ointment: Mild-moderate: half-inch ribbon 2-3 times daily; Severe: every 3-4 hours
Administration
- For ophthalmic use only
- Wash hands before use
- Do not touch dropper tip to eye or any surface
- Apply pressure to the inner corner of the eye for 1 minute after instillation
- Wait 5-10 minutes before other eye medications
- Use within 4 weeks of opening the bottle
Missed dose
If you miss a dose, consult your doctor.
Side effects
Common Side Effects:
- Eye irritation
- Burning sensation
- Itching, redness
- Conjunctival erythema
- Eyelid swelling
Precautions & warnings
- Prolonged use may cause corneal damage
- Discontinue if sensitivity reaction occurs
- Prolonged use may result in overgrowth of nonsusceptible organisms and fungi
- May cause temporary blurring of vision; do not drive immediately
- Do not wear contact lenses during active eye infection
Contraindications
- Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and other viral diseases of the cornea/conjunctiva
- Mycobacterial infections of the eye
- Fungal diseases of the eye
- Untreated purulent infection of the eye
- Hypersensitivity to any component
Drug interactions
- Etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, cyclosporine, amphotericin B: Increased nephrotoxicity or ototoxicity
- Miconazole: Decreased serum tobramycin levels
- Magnesium and other neuromuscular-blocking agents: Increased neuromuscular-blocking activity (potentially fatal)
Food interactions
Alcohol consumption is not relevant (topical application).
Use in pregnancy
Use in Pregnancy: Unsafe; evidence of fetal risk; use only in life-threatening situations; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safe during breastfeeding; human studies show insignificant passage into breast milk; consult your doctor.
Pediatric use
Safety and efficacy not established in children under 1 year
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Not applicable (topical application)
Hepatic Impairment: Not applicable (topical application)
Overdose effects
Overdose is not applicable (topical application); excessive use may cause eye irritation.
Storage conditions
Store below 25°C in a cool and dry place, protected from light; use within 4 weeks of opening; keep out of reach of children.
Chemical structure
Tobramycin