Generic
Trifarotene
3 brands available in the market
At a glance
Trifarotene cream is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.
Description
Trifarotene is an agonist of retinoic acid receptors (RAR), with particular activity at the gamma subtype. Stimulation of RAR modulates target genes associated with cell differentiation and inflammation.
Indications
- Acne vulgaris
Therapeutic class
Topical retinoid and related preparations
Pharmacological class
Topical Retinoid
Pharmacology
Trifarotene is an agonist of retinoic acid receptors (RAR), with particular activity at the gamma subtype. Stimulation of RAR results in modulation of target genes associated with cell differentiation and mediation of inflammation.
Mechanism of action
Acts as RAR gamma agonist, modulating cell differentiation and inflammation to treat acne.
Dosage
Adult and Child (9 years and older) Dose (Topical):
- Apply a thin layer to affected areas once daily in the evening on clean and dry skin
- Use moisturizer as frequently as needed from initiation of treatment
Administration
- For topical use only
- Avoid contact with eyes, lips, paranasal creases, mucous membranes
- Not for oral, ophthalmic or intravaginal use
- Do not apply to cuts, abrasions, eczematous or sunburned skin
- Avoid waxing
Missed dose
If you miss a dose, apply it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Application site irritation
- Application site pruritus
- Sunburn
- Erythema
- Scaling
- Dryness
- Stinging/burning
Precautions & warnings
- Skin irritation may occur; use moisturizer, reduce frequency, or temporarily suspend use
- Minimize unprotected exposure to ultraviolet rays
- Use sunscreen and protective clothing
- Discontinue if severe reactions persist
Contraindications
- Hypersensitivity to trifarotene or any excipients
Drug interactions
- Oral hormonal contraceptives (ethinylestradiol and levonorgestrel): topical application not expected to affect circulating concentrations
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Category C; clinical trials have not identified a drug-associated risk of major birth defects; caution advised.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Consider developmental and health benefits of breastfeeding along with mother's clinical need and potential adverse effects on infant.
Pediatric use
Safety and effectiveness not established in children below 9 years
Geriatric use
Clinical trials did not include subjects aged 65 years and over
Renal / hepatic impairment
Renal Impairment: Not applicable (topical application)
Hepatic Impairment: Not applicable (topical application)
Overdose effects
Overdose is not applicable (topical application).
Storage conditions
Do not store above 25°C. Protect from light. Keep out of reach of children.