Generic
Undenatured Type II Collagen
8 brands available in the market
At a glance
Undenatured Type II Collagen is a nutraceutical indicated for osteoarthritis, rheumatoid arthritis, joint pain & inflammation, difficulties in flexibility & mobility, joint discomfort & stiffness, impaired joint function, and strenuous exercise & sports.
Description
Undenatured Type II Collagen derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Joint pain & inflammation
- Difficulties in flexibility & mobility
- Joint discomfort & stiffness (knee extension)
- Impaired joint function
- Strenuous exercise & sports
Therapeutic class
Drugs for Osteoarthritis, Herbal and Nutraceuticals, Specific mineral preparations
Pharmacological class
Herbal and Nutraceuticals
Pharmacology
Undenatured Type II Collagen derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity.
Mechanism of action
Undenatured collagen II molecules contain active binding sites called epitopes which trigger oral tolerization. This process releases collagen-specific regulatory T-cells that migrate to joint areas and prevent T-cell release. It prevents collagenase enzyme secretion and slows inflammatory cytokine production.
Dosage
Adult Dose (Oral):
- 1 capsule daily with water or as directed by the physician
Administration
- Take orally
- Take as directed by a physician
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Generally well tolerated
- Overdose may cause constipation and headache
Precautions & warnings
- Contraindicated in patients with known hypersensitivity to chicken or egg
- Generally well tolerated at recommended dose
Contraindications
- Hypersensitivity to chicken or egg
Drug interactions
No known interactions.
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Lack of scientific evidence on the use of undenatured collagen II during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Lack of scientific evidence on the use of undenatured collagen II during lactation.
Pediatric use
Safety and efficacy not established in children
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Limited information
Hepatic Impairment: Limited information
Overdose effects
Symptoms: Constipation, headache.
Treatment: Supportive care.
Storage conditions
Keep away from direct sunlight and moisture. Store below 30°C in a cool and dry place. Keep out of reach of children.