Generic
Undenatured Type II Collagen + Glucosamine sulfate + Chondroitin Sulfate
4 brands available in the market
At a glance
Undenatured Type II Collagen + Glucosamine Sulfate + Chondroitin Sulfate + Methylsulfonylmethane is indicated for osteoarthritis, joint pain and inflammation, joint immobility and stiffness, rheumatoid arthritis, and strenuous exercise and sports injury.
Description
Undenatured Collagen II prevents breakdown of joint cartilage by releasing collagen-specific T-regulatory cells. Glucosamine is the essential building block of joint cartilage. Chondroitin maintains water and nutrients in cartilage. MSM maintains and repairs healthy joints, tendons, ligaments, and connective tissues.
Indications
- Osteoarthritis
- Joint pain and inflammation
- Joint immobility and stiffness
- Rheumatoid arthritis
- Strenuous exercise and sports injury
Therapeutic class
Drugs for Osteoarthritis, Herbal and Nutraceuticals, Specific mineral & vitamin combined preparations
Pharmacological class
Herbal and Nutraceuticals
Pharmacology
Undenatured Collagen II is derived from chicken sternum cartilage preventing breakdown of joint cartilage. Glucosamine is the essential building block of joint cartilage. Chondroitin is a structural component of cartilage. MSM maintains and repairs healthy joints, tendons, ligaments, and connective tissues.
Mechanism of action
Undenatured Collagen II releases collagen-specific T-regulatory cells, preventing cartilage breakdown and slowing inflammatory cytokine production. Glucosamine reduces synthesis of inflammatory mediators. Chondroitin maintains water and nutrients in cartilage. MSM reduces COX-2 and nitric oxide expression.
Dosage
Adult Dose (Oral):
- 1 tablet daily after a meal or as directed by the physician
Administration
- Take after a meal
- Take as directed by a physician
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Generally well tolerated
- Occasionally mild epigastric pain, constipation, diarrhea, bloating, and nausea
- Rarely headache and visual disturbance
Precautions & warnings
- Caution with anticoagulants
- Glucosamine sulfate can alter GI absorption of tetracycline, penicillin, and chloramphenicol
- Can be used with analgesics or anti-inflammatory drugs
Contraindications
- Hypersensitivity to Undenatured Collagen II, Glucosamine Sulfate, Chondroitin Sulfate, and MSM
- Contraindicated for patients under 18 years, phenylketonuria, and severe renal insufficiency
Drug interactions
- Anticoagulants: caution required
- Glucosamine sulfate can alter GI absorption of tetracycline, penicillin, and chloramphenicol
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Not recommended during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Not recommended during lactation.
Pediatric use
Contraindicated for patients under 18 years
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Contraindicated in severe renal insufficiency
Hepatic Impairment: Limited information
Overdose effects
Symptoms: Headache, visual disturbance.
Treatment: Supportive care.
Storage conditions
Do not store above 30°C, protect from light and moisture. Keep out of reach of children.