Generic
Vibegron
1 brands available in the market
At a glance
Vibegron is indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults.
Description
Vibegron is a potent, selective beta-3 adrenergic receptor agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity.
Indications
- Overactive bladder (OAB)
- Urge urinary incontinence
- Urgency
- Urinary frequency
Pharmacological class
β₃-adrenergic receptor agonist
Pharmacology
Vibegron is a potent, selective beta-3 adrenergic receptor agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity.
Mechanism of action
Stimulates beta-3 adrenergic receptors, relaxing detrusor smooth muscle and increasing bladder capacity.
Dosage
Adult Dose (Oral):
- 75 mg tablet once daily with or without food
Administration
- May be taken with or without food
- Swallow tablets whole
- Take at the same time each day
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Drug interactions
- Digoxin: increases maximal concentrations (Cmax) and systemic exposure (AUC); monitor digoxin concentrations
Food interactions
Food interactions are not significant.
Contraindications
- Hypersensitivity to Vibegron or any components of the product
Side effects
Common Side Effects:
- Urinary tract infection
- Nasal congestion
- Sore throat or runny nose
- Nausea
- Headache
- Diarrhea
- Upper respiratory tract infection
Use in pregnancy
Use in Pregnancy: No available data; insufficient to evaluate drug-associated risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: No data on presence in human milk, effects on breastfed infant, or effects on milk production.
Precautions & warnings
- Urinary retention has been reported; discontinue Vibegron if urinary retention develops
- Monitor digoxin concentrations when used concomitantly
Pediatric use
Safety and effectiveness not established in pediatric patients
Geriatric use
No dosage adjustment required in elderly
Renal / hepatic impairment
Renal Impairment: Limited information
Hepatic Impairment: Limited information
Overdose effects
Symptoms: No experience with inadvertent overdose.
Treatment: Symptomatic and supportive.
Therapeutic class
β₃-adrenergic receptor agonist
Storage conditions
Store below 30°C in a dry place, protect from light. Keep out of reach of children.